"Give with a free hand, but give only
-- J.R.R. Tolkien The Children of Hurin
I have nothing to sell you.
The purpose of this web site is to
provide you with information for when you meet with a
physician to discuss what can be done for someone suffering
from brain failure.
You will have a list of questions to ask, and sources to
read so that you can ask them intelligently. I want to
share some of the information I've accumulated in my search
to help my mother.
Synthetic pharmaceuticals and
physician supervised treatment is certainly the preferred
course of action to help the brain failure sufferer. But
while you wait for the physicians (who may have treatments)
to get off of their duffs and try something, here are
some things you can
try. Research the following multi-front attack:
30, 2008... The following material is old and needs
to be updated. See Patricia's
Protocol for what I feel are the essential supplements
she is getting.]
See also Dale's List
The following is speculation.
- to provide an alternative energy source due to
Acid - (a.k.a. IP6) to chelate
free metal ions involved with nerve cell damage
- to dissolve amyloid-β
proteins which might cause neuronal damage
- to prevent tau protein
corruption, induce neurogenesis
- to prevent tau proten correuption,
aggregation and undo aggregations
- to prevent
tau proten correuption, aggregation and undo aggregations
Blue - To prevent tau protein corruption,
aggregation, undo aggregations
already formed, and prevent neuronal
Unfortunately, medicines and therapies don't always work for
For the most part, we don't discuss health food, but rather,
naturally-sourced medicines from plants* and animals, and
therapies that are on the fringes of medical research. Most
medicines originate from plants and animals, so discussing and
trying those that may help is appropriate. Every new therapy
for treating a disease starts out as a radical idea on the
fringes that the mainstream is slow to accept.
Some of us want to try some of these unproven things because
we know that the clock is ticking and the conventional
"standard of care" doesn't help much.
The flow usually goes like this. Some observation is made
about an aspect of the disease or the effect of a substance.
Then people scour the available literature to find research to
back up the observation and report what they find. Finally,
some take it upon themselves to try something-- usually based
on a research paper they found-- and report on their success
or failure. We've had few successes. But it is important to
know what other people have tried so that the rest of us can
either duplicate a success or learn from a failure. If we know
what was tried, how much, how often, how long, and what with,
trial and error may lead us to a correct strategy.
It seems likely that there are more than one path that lead to
the same destination. MCT oils (used as a medicine) may work
for one a person on one path, but not for another. Eradication
of the Helicobacter pylori bacteria may halt the progression
of Alzheimer's disease for those individuals who have an
H.pylori infection, but not for those who's AD was initiated
by head injury or genetic predisposition.
So, is it possible that one man's medicine is another man's
*Note this observation from Schubert's page on the Salk
Institute's web site:
...Because plants lack an immune system, they instead
synthesize drug-like molecules to defend themselves against
infectious pathogens and insect predators. Most of these
molecules have numerous biological activities, and they are
the basis of much of the current pharmacopoeia. They have not,
however, been exploited for the treatment of chronic
Nutritional Alternative Protocols:
The PC Protocol:
to 3 times per day, at least 8 hours apart, if
Targetting amyloid beta and "oxidative
stress" from iron and
(~12mg/lb of body weight)
Acid (IP6): 1/2 tsp. (heaping ~400 to 500 mg) in orange
juice, on an empty
first thing in the morning, 1 hr before
and other excess minerals
1/2 cup, chopped (about 5
stalks)... for 3 weeks, every 6 months
Used to "dislodge" minerals and metals
like mercury, lead,
are later flushed out by IP6 or other
chelators (possibly curcumin?)
(red wine extract), 200mg, 1 to 2 times per
(Jarrow "Resveratrol Synergy":
Resveratrol 200mg, grape seed
skin 100mg, green tea 200mg, vitamin C 100mg)
(extract), 200mg, 1 to 2 times per day.
(N-acetyl-cisteine), 500mg, 2 times per day
and antioxidant (Jarrow ThioNac)
500 mg Optional if fruits or
juice are included in diet. Also,
taken simultaneously with NAC. See note 7.
~50 mg -Can be a "B
complex" with B6, B9, & B12
May need a 30 mg magnesium
supplement. Bananas are
a good source.
1000 mg Antioxidant properties
250 mg once per day (to start with) (Jarrow
A possible symptom reliever, to
improve mental abilities. Not
30 mg per day (to start with)
coenzyme Q10. To improve mental
hopefully slow disease progression
250 mg per day (Jarrow milk thistle)
8 oz. of cranberry juice cocktail per
day. To help prevent
(UTI). Also high in tannins.
Most pills are crushed and capsules opened. They are mixed
with about 6 oz. of applesauce and about 1/8 tsp. of cinnamon (to cover the taste of he
Target effect of the supplements:
1) The McDougall
diet of complex carbohydrates, whole grains, fruits,
animal protein, added fat, or dairy products.
There are many
health benefits to following this diet even if diet alone is
enough to address A.D. It basically
adheres to a vegan diet, but since small
amounts of meat on special holidays is OK, just
not the typical "three feasts per
day" American diet, it isn't a strict vegetarian
diet. Benefits commonly
reported that would help a vascular dementia
- Lowers cholesterol without drugs
- Lowers blood pressure
- Eliminates Type II diabetes
- Eliminate angina and allows the
body to reverse artery disease
(extract of the curry spice turmeric)
In studies done with transgenic mice,
curcumin "disaggregated" the amyloid-β
plaques that have been proven to cause the
symptoms of Alzheimer's disease.
Piperine found in abundance in common black
pepper has been found to increase
the amount of curcumin that gets into the
blood. But piperine may cause problems
absorbing other medications, so it may not be a
good idea to use it. Perhaps
using a little more black pepper on food would
be good enough. Curcumin is also
an iron and copper chelator.
Note: Curcumin may adversely augment
the effects of prescription blood thinners.
Acid (a.k.a. myo-inositol hexakisphosphate, InsP6, or
Another thing-- since
phytic acid is found naturally in abundance in whole
This supplement is generally sold as an
"immune system builder" for those
suffering from cancer. Since the elimination of excesss iron has
to have a positive influence on arresting the
progression of AD, phytic acid
supplementation may have a positive effect.
1000 to 2000mg per day (on an
empty stomach) for 30 to 90
days, along with
daily doses of curcumin, ginkgo, cilantro,
and garlic; toxic metal ions might
successfully flushed out of the body.
After the initial 30 to 90 days, a lesser amount
might be adequate for
Please note: Someone who is anemic (not
enough red blood cells) may need more
iron in their diet, and phytic acid would not be
grains, legumes, and nuts, the McDougall diet
might provide more than enough for
This herb is used in Europe to treat early
stages of dementia (from various
causes). It is claimed to be just about as
effective as those expensive
prescription drugs the pharmaceutical companies
are pushing. But that isn't much
of a recommendation.
It is also a
anti-coagulant. That's good for those at risk for a
stroke, but it
can magnify the effects of other anti-coagulant
drugs like prescription heparin.
This is another natural anti-coagulant and
a mild metal chelator.
6) Vitamin B12 and Folic Acid
7) Vitamins C and E
Note: avoid administering vitamin C and NAC
simultaneously during inflammatory
response, as it may promote hydroxyl radical
formation in the presence of iron
8) Cilantro-- three
weeks of 1/4 cup (chopped) per day for 3 weeks
This is part of a "home toxic metal
chelation" procedure. Cilantro is said to
"dislodge" metal ions that are just hanging
around in various body tissues, and
up to no good. But after the metals are
flushed out into the open, so to speak,
you need a metal chelator to grab onto them, and
flush them out.
9) Scyllitol (a.k.a.
scyllo-inositol, cocositol, quercinitol)
In mice, this naturally occuring plant
sugar does wonders for AD. It has been
proven to actually dissolve the amyloid beta
plaques that are thought to cause
brain damage in AD sufferers; and restore near
normal mental capacity. We can
only hope that it would be as effective in
humans. However, even in plant foods
rich in scyllitol, like the coconut, it is only
something like 500 parts per
million. Ethanol (grain alcohol)
consumption has been linked to increased levels
of scyllitol in the brain, but ethanol itself
may have side effects that make
consuming it in large enough quantities to have
an effect inadvisable. So, what
we need is a source for scyllitol supplements,
or a process for concentrating it
from plant scources.
12) Green Tea
13) CDP-choline (a.k.a. citicoline)
15) Lithium (lithium orotate)
16) Medium Chain Triglycerides (MCT)
17) Cinnamon (water soluble
19) Acetyl-L Carnitine (or
Sharon Comden's Supplement Protcol for combating
her Corticobasal Syndrome symptoms
Longvida curcumin,1000 mg (bioavailable
curcumin, available in capsule and powder forms from
Vitamin C 500 mg (at least)
[ 8/14/2012: reports that
she "increased the curcumin in the regimen to three times a
day and a total daily intake 3500 mg (3.5 grams)." That's a
LOT of curcumin!]
DHA/omega 3 fish oil 1200 mg (one enteric coated, from
Costco, Kirkland brand)
- on an empty stomach in the morning
and at bedtime.
CoQ10 600 mg [Later revised down
(NeuroCoatT, 1 tablespoon twice a day dissolved in a beverage
or with food),
commercial sweetener shown to be safe and beneficial with Huntington's
seems to improve articulation as well and compliments the
action of the Longvida curcumin.
Baby aspirin every
Improvements in speech after four weeks on the
At 4.5 weeks the
curling fingers were gone, and gait/limb movements returned to
The dose of Longvida curcumin was lowered my to 500 mg twice a day after
a few weeks, following the "initial induction phase" when the
curcumin levels are rising to therapeutic levels in the brain.
[I think I would
investigate adding MCT oils to the
regimen at least during the "initial induction phase" since the damaged but
still viable brain cells are having trouble using
glucose. See Dale's List
for an example.]
these files: Neuro-preservation
Dr. Mary Newport's Regimen
4 tablespoons of 50% MCT oil + 50% Coconut Oil at each meal and
then another 2 tablespoons at bed time.
HYPE protocol for Dementia with Lewy Bodies (DLB):
For your consideration, a protocol devised by "NO HYPE" on the
"Current protocol [March, 2008] consists of:"
TUDCA [tauroursodeoxycholic acid - NO HYPE reported good results
before adding this]
grape seed extract
silymarin [extract of milk thistle?]
CDC choline [CDP-choline? stands for cytidine
EPA/DHA [fish oil?]
"Supplements that I would like to add:"
Scyllitol [need a source!]
"Note: considering EDTA for iron chelation"
timespan of about 10 months, I have literally witnessed a
DRAMATIC, visible transformation in physical appearance,
cognitive function, and overall way of life."
"I started him on the [protocol] (along with other supplemental
nutrients), and within about 3-4 WEEKS, he was walking WITHOUT
the walker, his posture had SIGNIFICANTLY improved, the severity
of autonomic dysfunction had lessened, and the tasks that were a
nightmare in previous weeks soon became simple once again."
"Additionally in my opinion, I STRONGLY feel that these
antioxidants when taken regularly, will significantly reduce the
risk of developing this disease."
"With the exception of alpha-synuclein accumulation and somatic
dysfunction, inflammation and oxidation are the key
physiological substrates underlying the progression of
"The inhibition of oxidation and the attenuation of inflammation
can be achieved (among other nutrients) via polyphenol
antioxidants. Polyphenols have been found to effectively inhibit
ROS (wich in excess, causes significant damage and/or death to
cell structures) and peroxynitrite (one of the main mediator
"Other non-polyphenol antioxidants that aquire the synergistic
potential to accomplish the above mentioned tasks include:
N-Acetyl-Cysteine, ALA, ubiquinol/idebenone, curcumin, selenium,
fish oil, vitamin C, vitamin A, vitamin E, melatonin, ect. These
antioxidants will also assist in inhibiting excessive cytochrome
P450-induced, free radical cell damage."
1. Galantamine (4-16mg/day)
Prevents the breakdown of acetylcholine, facilitates memory
functions, appears to modulate both beta amyloid plaques and
2. Alpha GPC (500mg-1.5grams/day)
Precursor of acetylcholine, increases human growth hormone
secretion to build new cells, crosses the blood-brain-barrier
(BBB) better than any other choline source.
3. Spirulina (300-800mg/day)
Enhances the immune system, exceptional protein source,
modulates cytokine and tumor necrosis factor (TNF) proteins that
contribute to AD pathogenesis, source of B vitamins and omega
fatty acids DHA and EPA.
4. Ashwagandha (500-800mg/day)
Boosts immune system functioning especially in regards to the
brain, facilitates nervous system rejuvenation, prevents
stress-related mental decline.
5. Fish Oil (1,000mg/day)
Exceptional source of omega fatty acids that help fuel the
6. Curcumin (1000-3000mg/day)
Helps immune cells clear out amyloid-beta plaque build-up.
7. Resveratrol (200-1,000mg/day)
Reduces inflammation, attacks cancer cells, and aids in
8. Piracetam (500-1,000mg/day)
Increases blood flow and oxygen to the brain, and helps to slow
decay of brain cells.
9. High quality multi-vitamin rich in B vitamins
Critical to the formation of red blood cells, assists in overall
brain development and nutrition.
10. Cinnamon (1,000-3,000mg/day)
May help with Tau tangles, modulates glucose.
11. Blueberry Extract (500mg/day)
Exceptional antioxidant, high anthocyanin content, vitamins C
12. Ginkgo Biloba (500-1,000mg/day)
Increases cerebral circulation and brain cell oxidation.
13. Green Tea Extract (500mg/day)
Excellent antioxidant with L-theanine.
14. Uridine (50-100mg/day)
Building block of RNA and DNA, contributes to the production of
15. Aspirin (250-500mg/day)
Anti-inflammatory, increases cerebral circulation, and manages
16. Acetyl-l-carnitine (1,000mg/day)
Reverses damage to mitochondria associated with aging and has
17. Cat's Claw (uncaria tomentosa)
Assist's the immune system, reduces inflammation, help with
beta-amyloid plaques, inhibits TNF (tumor necrosis factor).
And please do not forget a healthy diet consisting of fresh
fruits and vegetables, fish, nuts and seeds (such as walnuts),
and clean water.
Amount Per day
B-12 (sublingual methylcobalamin) 5000
8 mg 3
10 mg 2
500 mg 2
Alpha lipoic acid
600 mg 3
120 mg 2
600 mg 2
60 mg 1
600 mg 5
500 mg 3
500 mg 4
3 mg 2
100 mg 3
Acetyl L-carnitine arginate DiHCl 300
Acetyl L-carnitine HCl
300 mg 2
50 mg 2
IP6 (inositol hexaphosphate)
500 mg 2
He also takes multi-minerals, B, C, E, and K vitamins, CoQ-10,
folic acid, and a few others.
I have posted on this topic earlier this month but will
update you with my observations. I am providing a host of
treatments for my wife that include at least a dozen
supplements and a few prescribed medications, the most
obviously effective being prazosin for sleep and for emotional
outbursts including sundowning and also delusions.
Additionally, she has been receiving acyclovir 200 mg 2x/day
for several months now. She is APOE4+ meaning she has
the so-called AD gene. She has a life long history of
cold sores occurring at a rate around 6/year. Before
trying acyclovir I did try l-Lysine but stopped it when she
developed a cold sore on her lower lip that would not go away
until I started acyclovir at which time it resolved
quickly. Because she is receiving so many supplements
and three prescribed medications (Aricept, prazosin, and
Acyclovir) it is impossible for me to be able to determine
what if anything might be helpful for her. However, it
is my impression that her AD has been progressing very slowly
if at all over the past several months so it is indeed
possible that acyclovir might be a contributor to slowing or
perhaps even halting for the moment disease progression.
However, just to be cautious, I should add that it is my
impression that AD progression can be highly variable within
as well as between patients so I may simply be detecting a
temporary lull in her disease progression that has little or
nothing to do with the many things I am giving her to treat
her condition. Since starting acyclovir at a relatively low
dose, she has had one mild and short lived cold sore. To
conclude, it appears that for the past several months my
APOE4+ wife who has a long standing history of cold sores may
be experiencing some sort of remission in AD
progression. This happy result may be due to a
combination of factors, or may be due to nothing I am doing
for her at all. However, in the treatment mix I am
giving her is included acyclovir. I have had her on Nutiva
coconut oil for maybe 2 yrs and more recently MCT oil (10
drams 2x/day). It is possible the changes I have observed may
be attributable to that as well.
I do believe something
is working for her...just not sure what.
Natural options for Alzheimer’s
Disease treatment - Alternatives to Alzheimer's Medication
scientists have not fully determined the actual causes of
Alzheimer’s disease, a number of treatment options have been
proposed or tried over the years. Although much more research
needs to be done in order to find out the role of these
supplements in Alzheimer's disease treatment, I think it is
appropriate to give them a try since this condition currently
has no cure or effective treatment. You are not likely to find
this information in any official Alzheimer's disease
association or Alzheimer's foundation. Some natural options
for Alzheimer's disease treatment or prevention include
(discuss with your doctor first)
[Interesting and lengthy
discussion. Note the part about "inhaled anesthetics
isoflurane and halothane, may be another cause of Alzheimer's
Home Preface Brain Failure Notes References
pg. 1 References pg. 2
Patricia's Protocol Tauopathy
You can reach me by mai|ing to
"perpetualcommotion.com", at gmail.
Inception: June 5, 2006