"Give with a free hand, but give only your own."
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- Resveratrol -

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See also Metformin

Extending Life and Fighting Disease with Resveratrol
Life Extension magazine article(8pgs)
August 2009
by Julius Goepp, MD.

Scientists are dicovering significant additional benefits that resveratrol confers in fighting aging and degenerative disease.

While much of this research was initiated by a prolific group at Harvard University and in the biotech industry, scientists around the globe are now making unprecedented discoveries that define resveratrol's multiple preventive and therapeutic potentials.

Most exciting are findings showing how resveratrol may help protect against devastating age-related diseases including cancer, diabetes, atherosclerosis and Alzheimer's...."

...We've long known that resveratrol has potent antioxidant and anti-inflammatory effects, making it a key item in our armamentarium of supplements that can prevent age-associated chronic illnesses. The real news is that resveratrol continues to be linked to the life-extending effects of the powerful sirtuin molecules that control the fundamental processes associated with aging itself. By potently activating sirtuins, resveratrol stabilizes DNA to prevent cancerous changes, switches on antioxidant and anti-inflammatory defense mechanisms native to cells, and even instructs certain cells to commit organized suicide by apoptosis. The end result is an almost incredible array of health benefits, from reduction in cardiovascular risk factors to protection against neurodegenerative disease to cancer prevention. Indeed, resveratrol is being actively explored now by big pharmaceutical companies eager to cash in on its potency by creating new drugs derived from the natural molecule....

Compound Found in Red Wine Neutralizes Toxicity of Proteins Related to Alzheimer's
ScienceDaily (June 22, 2010)
... research led by Rensselaer Professor Peter M. Tessier. The findings, published in the May 28 edition of the Journal of Biological Chemistry... "We've shown how resveratrol has very interesting selectivity to target and neutralize a select set of toxic peptide isoforms. Because resveratrol picks out the clumps of peptides that are bad and leaves alone the ones that are benign, it helps us to think about the structural differences between the peptide isoforms." Isoforms are different packing arrangements of a particular peptide. Deformations of a particular peptide -- the Aβ1-42 peptide -- have been linked to Alzheimer's disease. Improperly folded peptides have been shown to collect in accumulations called "plaques" within the brain. Those plaques are often found near areas of cell death in diseased brains...

Life span extension by resveratrol, rapamycin, and metformin: The promise of dietary restriction mimetics for an healthy aging.
Mouchiroud L, Molin L, Dallière N, Solari F.
Biofactors. 2010 Sep;36(5):377-82.
Source: UMR, CNRS Université Lyon, Centre Léon Bérard, France.
Life expectancy at the turn of the 20th century was 46 years on average worldwide and it is around 65 years today. The correlative increase in age-associated diseases incidence has a profound public health impact and is an important matter of concern for our societies. Aging is a complex, heterogeneous, and multifactorial phenomenon, which is the consequence of multiple interactions between genes and environment. In this review, we survey animals models that have been of great help for both investigating mechanism of aging and identifying molecules, which slow down the onset of age-related diseases. Resveratrol (RSV) is one of those. We will report evidences supporting RSV as a molecule that acts by mimicking the beneficial effects of dietary restriction, and may share common downstream targets with rapamycin and metformin. Although those molecules do not reveal all the secrets of the fountain of youth, they may help us maintaining the quality of life in the old age.
PMID: 20848587 [PubMed]

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