Brain Failure:  Types and Causes of Brain Failure

See The Grand Index for much more information

Alzheimer's Disease
Vascular Dementia (multi-infarct dementia)
Vascular Dementia (lacunar disease)
Parkinson's Disease
Dementia with Lewy Bodies
Normal Pressure Hydrocephalus
Hydrocephalus Ex-Vacuo
Corticobasal Degeneration (CBD)
Frontotemporal Lobar Degeneration
Frontotemporal Dementia (FTD)
Primary Progressive Aphasia
Semantic Dementia
Progressive Nonfluent Aphasia
Shy-Drager syndrome
DLB disease
olivopontocerebellar atrophy (OPCA)
multiple sclerosis
brainstem neoplasm
progressive supranuclear palsy (PSP)

(1) parkinsonian syndromes associated with brain iron accumulation
 - Parkinson’s disease
 - diffuse Lewy body disease
 - parkinsonian type of multiple system atrophy
 - progressive supranuclear palsy
 - corticobasal ganglionic degeneration(CBD or CBGD)
 - Westphal variant of Huntington’s disease

2) monogenetically caused disturbances of brain iron metabolism associated with parkinsonian
 - aceruloplasminemia
 - hereditary ferritinopathies affecting the basal ganglia
 - panthotenate kinase associated neurodegeneration type 2

3) Tauopathies (and conditions that develop tauopathies)
   1. Aging (hippocampal region, 100% > 75y)
   2. Alzheimer’s disease (familial, sporadic)
   3. Amyotrophic lateral sclerosis/PD complex of Guam
   4. Argyrophilic grain disease
   5. British type amyloid angiopathy
   6. Corticobasal degeneration (corticobasal ganglionic degeneration)
   7. Dementia pugilistica/autism with self-injury behaviour
   8. Down’s syndrome
   9. FTDP-17
  10. Gerstmann-Straussler-Scheinker disease (rarely)
  11. Hallenvorden-Spatz disease
  12. Inclusion body myositis
  13. Multisystem atophy
  14. Myotonic dystrophy
  15. Niemann-Pick disease type C
  16. Parkinson with dementia of Guadeloupe
  17. Pick’s disease
  18. Presenile dementia with tangles and calcifications
  19. Prion protein cerebral amyloid angiopathy
  20. Progressive supranuclear palsy
  21. Post-encephalitic parkinsonism
  22. Subacute sclerosing panencephalitis
  23. Tangle only dementia

The Dementia Matrix

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Updated May 10, 2008
Inception January 4, 2008