"Give with a free hand, but give only your own."
 -- J.R.R. Tolkien The Children of Hurin
- Fisetin -

General Information:

Wikipedia entry:
Dr. Ray Shahelien entry: 



From Wikipedia:

Search for fisetin from online supplement suppliers, such as Amazon.com or Swanson.com

Flavonoids could represent two-fisted assault on diabetic complications and nervous system disorders
Salk Scientists Say: It's not an Apple a day after all - it's Strawberries!
June 27, 2011

Fisetin supplement, flavonoid extract, memory help? by Ray Sahelian, M.D.

A natural chemical found in strawberries boosts memory in healthy mice
Maher: "That suggested to us that these compounds might be particularly beneficial, since they might not only protect neural cells from dying but might be able to promote new connections between nerve cells."

Fisetin Shows Promise Against Huntington's Disease

Strawberries Outperform An Apple A Day

37 strawberries a day keep doctors away

From Sept. 2008… dosage discussion…

PubMed search on "Fisetin"

A Series of Novel Neuroprotective Blood Brain Barrier Penetrating Flavonoid Drugs to Treat Acute Ischemic Stroke.
Lapchak PA.
Source: Director of Translational Research, Cedars-Sinai Medical Center, Department of Neurology, Davis Research Building, D-2091, 110 N. George Burns Road, Los Angeles, CA 90048 USA.
Curr Pharm Des. 2012 May 11.

Stroke is the 4th leading cause of death and disability in adults in the USA. However, in the majority of patients, the detrimental effects of an ischemic insult go untreated because of the lack of efficacious neuroprotective compounds. Using naturally occurring compounds as a building block to create efficacious neuroprotective compounds that cross the blood brain barrier may eventually benefit the stroke patients. However, historically, the development of novel compounds has been fraught with problems including lack of significant pleiotropic activity, inability to effectively cross the blood brain barrier and poor bioavailability. This article details, in a stepwise manner, the synthesis and in vitro screening steps used to produce new flavonoids that have increased neuroprotective activity compared to the parent compound fisetin. Moreover, as a preliminary de-risking step, select compounds have been screened in a transfected Madin Darby canine kidney cell assay as a measure of blood brain barrier penetration. Initial de-risking steps have allowed us to identify a series of BBB-penetrating neuroprotective candidates for further development.
PMID: 22574983 [PubMed]

The flavonoid fisetin attenuates postischemic immune cell infiltration, activation and infarct size after transient cerebral middle artery occlusion in mice.
Gelderblom M, Leypoldt F, Lewerenz J, Birkenmayer G, Orozco D, Ludewig P, Thundyil J, Arumugam TV, Gerloff C, Tolosa E, Maher P, Magnus T.
Source: Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
J Cereb Blood Flow Metab. 2012 May;32(5):835-43. doi: 10.1038/jcbfm.2011.189. Epub 2012 Jan 11.
The development of the brain tissue damage in ischemic stroke is composed of an immediate component followed by an inflammatory response with secondary tissue damage after reperfusion. Fisetin, a flavonoid, has multiple biological effects, including neuroprotective and antiinflammatory properties. We analyzed the effects of fisetin on infarct size and the inflammatory response in a mouse model of stroke, temporary middle cerebral artery occlusion, and on the activation of immune cells, murine primary and N9 microglial and Raw264.7 macrophage cells and human macrophages, in an in vitro model of inflammatory immune cell activation by lipopolysaccharide (LPS). Fisetin not only protected brain tissue against ischemic reperfusion injury when given before ischemia but also when applied 3 hours after ischemia. Fisetin also prominently inhibited the infiltration of macrophages and dendritic cells into the ischemic hemisphere and suppressed the intracerebral immune cell activation as measured by intracellular tumor necrosis factor α (TNFα) production. Fisetin also inhibited LPS-induced TNFα production and neurotoxicity of macrophages and microglia in vitro by suppressing nuclear factor κB activation and JNK/Jun phosphorylation. Our findings strongly suggest that the fisetin-mediated inhibition of the inflammatory response after stroke is part of the mechanism through which fisetin is neuroprotective in cerebral ischemia.

PMID: 22234339[PubMed - in process] PMCID: PMC3345911    [Available on 2013/5/1]

Modulation of multiple pathways involved in the maintenance of neuronal function during aging by fisetin.
Maher P.
Genes Nutr. 2009 Sep 10.
Source: The Salk Institute for Biological Studies, 10010 N. Torrey Pines Rd., La Jolla, CA, 92037, USA

Multiple factors have been implicated in the age-related declines in brain function. Thus, it is unlikely that modulating only a single factor will be effective at slowing this decline. A better approach is to identify small molecules that have multiple biological activities relevant to the maintenance of brain function. Over the last few years, we have identified an orally active, novel neuroprotective and cognition-enhancing molecule, the flavonoid fisetin. Fisetin not only has direct antioxidant activity but it can also increase the intracellular levels of glutathione, the major intracellular antioxidant. Fisetin can also maintain mitochondrial function in the presence of oxidative stress. In addition, it has anti-inflammatory activity against microglial cells and inhibits the activity of 5-lipoxygenase, thereby reducing the production of lipid peroxides and their pro-inflammatory by-products. This wide range of actions suggests that fisetin has the ability to reduce the age-related decline in brain function.
PMID: 19756810 [PubMed] PMCID:PMC2775892

NOTE: Look for research articles about fisetin by Dave R. Schubert and/or Pamela Maher.

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Updated: July 2, 2012
Inception: July 2, 2012