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- Vitamin C -


General Information:

Names:
Wikipedia entry:
Dr. Ray Shahelien entry: 

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Observations:

Treatment With Vitamin C Dissolves Toxic Protein Aggregates in Alzheimer's Disease
Do supplements work????

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Known sources:


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Natural sources:


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References:

Treatment With Vitamin C Dissolves Toxic Protein Aggregates in Alzheimer's Disease
ScienceDaily (Aug. 18, 2011)
"When we treated brain tissue from mice suffering from Alzheimer's disease with vitamin C, we could see that the toxic protein aggregates were dissolved. Our results show a previously unknown model for how vitamin C affects the amyloid plaques," says Katrin Mani, reader in Molecular Medicine at Lund University.
"Another interesting finding is that the useful vitamin C does not need to come from fresh fruit. In our experiments, we show that the vitamin C can also be absorbed in larger quantities in the form of dehydroascorbic acid from juice that has been kept overnight in a refrigerator, for example."
http://www.sciencedaily.com/releases/2011/08/110818101645.htm

Suppression of Amyloid β A11 Antibody Immunoreactivity by Vitamin C: Possible Role Of Heparan Sulfate Oligosaccharides Derived From Glypican-1 By Ascorbate-induced, Nitric Oxide (NO)-catalyzed Degradation.
F. Cheng, R. Cappai, G. D. Ciccotosto, G. Svensson, G. Multhaup, L.-A. Fransson, K. Mani.
Journal of Biological Chemistry, 2011; 286 (31): 27559 DOI: 10.1074/jbc.M111.243345
http://www.lunduniversity.lu.se/o.o.i.s?news_item=5638&id=24890


Vitamins C and E May Protect Against Mental Decline

"We believe antioxidants like vitamins C and E may protect against vascular dementia by limiting the amount of brain damage that persists after a stroke," said study author Kamal Masaki, MD, of the University of Hawaii in Honolulu. "The supplements may also play a role in providing protection against brain cell and membrane injury involved in many aging-related diseases, thus resulting in significantly higher scores on mental performance tests in later life."
http://healthlink.mcw.edu/article/954383616.html

Vitamin C injections ease ovarian-cancer treatments
High doses reduce chemotherapy side effects in humans and fight tumours in mice.

Heidi Ledford
Nature
05 February 2014
...They noticed that earlier trials had partially relied on intravenous administration of high doses of vitamin C, or ascorbate, whereas the larger follow-up studies had used only oral doses of the drug.

This, they reasoned, could be an important difference: ascorbate is processed by the body in different ways when administered orally versus intravenously. Oral doses act as antioxidants, protecting cells from damage caused by reactive compounds that contain oxygen. But  vitamin C given intravenously can have the opposite effect by promoting the formation of one of those compounds: hydrogen peroxide. Cancer cells are particularly susceptible to damage by such reactive oxygen-containing compounds...
http://www.nature.com/news/vitamin-c-injections-ease-ovarian-cancer-treatments-1.14673

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Updated: July 2, 2012
Inception: July 2, 2012