"Give with a free hand, but give only your own."
 -- J.R.R. Tolkien The Children of Hurin
- Tannins -

General Information:

Wikipedia entry:
Dr. Ray Shahelien entry: 


Tannins and Tannic Acid:

See also cinnamon
         grape seed extract
         tau busters

I found this interesting chart of some study of the properties of some compounds to inhibit tau oligomer formation. As I understand it, CBD (corticobasal degeneration) is thought to be the result of tau protein accumulations?


" Compounds inhibiting aggregation of beta amyloid may inhibit tau oligomer formation (morin), may have no effect (curcumin) or facilitate tau oligomer formation (Congo red, ThS)
Genistein, a neuroprotective antioxidant, may also function as an inhibitor of aggregation
A novel compound inhibiting tau oligomer formation was found using this assay (4-amino 1,1'-azobenzene - 3,4-disulfonic acid)"

Tannic acid is also mentioned as a tau oligomer inhibitor. I know what tannic acid is. I found that morin is a plant flavonoid like silymarin, but I don't know much about it.

I wonder what plants are high in morin? I wonder if it crosses the blood/brain barrier? I wonder if tannic acid does?

If tannic acid is a tau oligomer inhibitor, and if it crosses into the brain, I wonder if consuming foods or supplements high in tannins would be helpful.

Wikipedia lists these foods as high in tannins:

+ tea
+ wine (especially red wine)
+ pomegranates
+ persimmons
+ berries (cranberries
+ beer (some, from hops)
+ legumes (red beans, black beans)

From Wikipedia: "The term [tannin] is widely applied to any large polyphenolic compound containing sufficient hydroxyls and other suitable groups (such as carboxyls) to form strong complexes with proteins and other macromolecules."  So, not all tannins are "tannic acid", and I haven't found which type of tannin would inhibit tau oligomer formation.

NOTE:  "proanthocyanidins" are related to tannins.  See Wikipedia.

Known sources:

Natural sources:





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Updated: July 2, 2012
Inception: July 2, 2012