www.perpetualcommotion.com
"Give with a free hand, but give only your own."
 -- J.R.R. Tolkien The Children of Hurin
- Multifunctional Cocktail -


General Information:

Names:
Wikipedia entry:
Dr. Ray Shahelien entry: 

********************************************************************************************
Observations:


See also Pyruvate
         Creatine
         Niacinamide
         Anti-oxidant trio therapy
         Mitochondrial Dysfunction

Phase I trial: Active (NCT00605930 on clinicaltrials.gov) (as of September 11, 2010).

"A bar of 2 gm of pyruvate and 1 gm of creatine, and a pill of 1 gm of niacinamide once a day for 24 weeks."
http://clinicaltrials.gov/ct2/show/NCT00605930?term=NCT00605930&rank=1

[From PubMed ID#: 20472654]

See:

Rational therapeutic approaches to progressive supranuclear palsy
Brain 2010: 133; 15781590
http://brain.oxfordjournals.org/content/133/6/1578.full.pdf+html

Table 1 of the above article lists "puruvate".  This must be a typo.  In the text, it refers to "pyruvate".

"Pyruvate is a free radical scavenger..."

Fernandez-Gomez FJ, Pastor MD, Garcia-Martinez EM, Melero-
Fernandez de Mera R, Gou-Fabregas M, Gomez-Lazaro M, et al.
Pyruvate protects cerebellar granular cells from 6-hydroxydopamineinduced cytotoxicity by activating the Akt signaling pathway and increasing glutathione peroxidase expression. Neurobiol Dis 2006;
24: 296307.

Wang X, Perez E, Liu R, Yan LJ, Mallet RT, Yang SH. Pyruvate protects
mitochondria from oxidative stress in human neuroblastoma SK-N-SH
cells. Brain Res 2007; 1132: 19.


********************************************************************************************
Known sources:


********************************************************************************************
Natural sources:


********************************************************************************************
References:




********************************************************************************************

 


~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

Home  Preface  Brain Failure  Notes Notes II References pg. 1  References pg. 2
Nutritional Alternatives  Patricia's Protocol  Tauopathy Discussion Forum
Correspondence  Newsletters  Poems  Memory Enhancement

Click to join tauopathies


********************************************************************************************

Questions or comments, contact "perpetualcommotion.com" at gmail.com

Updated: July 2, 2012
Inception: July 2, 2012