www.perpetualcommotion.com
"Give with a free hand, but give only your own."
 -- J.R.R. Tolkien The Children of Hurin
- YGS/YKS Yi-Gan San (YGS) -


General Information:

Names:
Wikipedia entry:
Dr. Ray Shahelien entry: 

********************************************************************************************
Observations:

YGS/YKS Yi-Gan San (YGS), Yokukansan (YKS)

See also Ferulic Acid

... I want to introduce you to a new alternative medicine originally formulated by a Chinese gentleman, Xue Kai and his son, Xue ji, in Ming dynasty China in 1555 as a remedy for restlessness and agitation in children. The formulation is called Yi-Gan San (YGS), later adapted by the Japanese and called Yokukansan (YKS) around the 5th century.  For brevity I will usually refer to the Japanese version (YKS) as it has virtually all the accessible research. The formulation of YGS and also YKS includes a mixture of dried herbs: 4 g of Atractylodis lancea rhizome, 4g of Poria, 3 g of Cnidii rhizome [Ferulic acid is a component of Cnidii], 3 g of Angelicae radix, 2 g of Bupleuri radix, 1.5 g of Glycyrrhizae radix and 3 g of Uncariae uncis cum ramulus. The recommended dose is: 2,5 grams of YGS/YKS powder (1.08 g extract) 3x/day. In Japan, YKS has been approved by the Ministry of Health, Labour and Welfare as prescriptions covered under the National health Insurance plan. It is widely reported that the benefits of YGS/YKS are probably attributable to the formulation as a whole, rather than to the individual compounds...
http://alzheimers.infopop.cc/eve/forums/a/tpc/f/762104261/m/4384001397



Pilot study of pharmacological treatment for frontotemporal dementia: effect of Yokukansan on behavioral symptoms.
Psychiatry Clin Neurosci. 2010 Apr;64(2):207-10.
Kimura T, Hayashida H, Furukawa H, Takamatsu J.
Source

Division of Clinical Research, National Hospital Organization Kikuchi Hospital, 208 Fukuhara, Koshi, Kumamoto 861-1116, Japan. tkimura@kikuti.hosp.go.jp
Abstract

The aim of the present study was to investigate the efficacy of Yokukansan in improving behavioral symptoms of frontotemporal dementia. This study was a prospective, open-label trial of daily Yokukansan for 4 weeks in 20 frontotemporal dementia patients. Yokukansan treatment was found to significantly improve scores for the Neuropsychiatric Inventory and the Stereotypy Rating Inventory. No adverse effects or significant changes in physical findings and laboratory data occurred except for hypokalemia in two cases. The results indicate that Yokukansan can alleviate the behavioral symptoms of frontotemporal dementia. (The clinical trial registration number is UMIN000002704).

PMID:20447015 [PubMed]
http://www.ncbi.nlm.nih.gov/pubmed/20447015

Five cases of frontotemporal dementia with behavioral symptoms improved by Yokukansan
Kimura T, Hayashida H, Furukawa H, Takamatsu J.
Psychogeriatrics Volume 9, Issue 1, pages 38–43, March 2009 (Japanese Psychogeriatric Society)
Article first published online: 27 MAR 2009

Abstract

Herein, we present five cases with frontotemporal dementia whose behavioral symptoms were improved by Yokukansan, a traditional Japanese medicine (Kampo). All five patients were prescribed Yokukansan (7.5 g/day) to reduce their symptoms. The patients' symptoms were evaluated comprehensively using the Neuropsychiatric Inventory (NPI) and the Stereotypy Rating Inventory (SRI) before and 4 weeks after Yokukansan treatment. The mean (± SD) scores on the NPI and the SRI before treatment were 55.6 ± 5.4 and 22.2 ± 6.5, respectively. After treatment, these scores were 30.0 ± 7.8 and 11.6 ± 7.5, respectively. Yokukansan was effective for the treatment of clinical symptoms in all five patients without adverse effects and significant changes in laboratory data. Although antipsychotic drugs have been used to control behavioral symptoms, their associated adverse effects frequently impact on the activities of daily living and quality of life of treated patients. The present cases suggest significant improvement of behavioral symptoms in frontotemporal dementia with Yokukansan treatment, leading to probable benefit of the use of Yokukansan in individuals with frontotemporal dementia.
DOI: 10.1111/j.1479-8301.2008.00261.x
Full text: http://onlinelibrary.wiley.com/doi/10.1111/j.1479-8301.2008.00261.x/full

********************************************************************************************
Known sources:

********************************************************************************************
Natural sources:


********************************************************************************************
References:




********************************************************************************************

 


~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

Home  Preface  Brain Failure  Notes Notes II References pg. 1  References pg. 2
Nutritional Alternatives  Patricia's Protocol  Tauopathy Discussion Forum
Correspondence  Newsletters  Poems  Memory Enhancement

Click to join tauopathies


********************************************************************************************

Questions or comments, contact "perpetualcommotion.com" at gmail.com

Updated: July 2, 2012
Inception: July 2, 2012