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- Pancreatic Cancer -
General Information:
Names:
Wikipedia entry:
Dr. Ray Shahelien entry:
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Observations:
Garcinol is found within the rinds of
the Garcinia indica fruit,
otherwise known as mangosteen.
Lots of
intesting info:
http://www.pancan.org/section_research/pdf/news_and_updates/PC%20News%20and%20Updates%20-%20November%202011.pdf
University
of Iowa study tests ketogenic diet for lung, pancreatic cancers
http://fyi.uiowa.edu/11/08/ui-study-diet-cancers/
Researchers with UI Health Care have received a two-year,
$340,023 grant from the National Cancer
Institute to investigate whether a ketogenic diet (high fat, low
carbohydrate) can increase the
effectiveness of radiation and chemotherapy for lung and
pancreatic cancer. The researchers hope that
the ketogenic diet will deprive cancer cells of glucose and
force them to rely on their flawed
mitochondrial metabolism, causing oxidative stress and making
the cancer cells more susceptible to
chemotherapy and radiation.
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Known sources:
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Natural sources:
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References:
J Oncol. 2012;2012:709739. Epub 2012 May 23.
Synergistic effect of garcinol and curcumin on antiproliferative and
apoptotic activity in pancreatic cancer cells.
Parasramka MA, Gupta SV.
Source
Department of Nutrition and Food Science, College of Liberal Arts
and Sciences, Wayne State University, 3009 Science Hall, Detroit,
MI 48201, USA.
Abstract
Pancreatic cancer (PaCa) is a major health concern due to its
aggressiveness and early metastasis. Current treatments for PaCa
are limited by development of resistance against therapy. As an
alternative strategy, we assessed the combinatorial effect of
dietary compounds, garcinol and curcumin, on human PaCa cells (BxPC-3
and Panc-1). A significant (P < 0.05) dose-dependent reduction
in cell viability and increase in apoptosis were observed in both
cell lines as compared to untreated controls. A combination index
(CI) value < 1, for a two-way comparison of curcumin and
garcinol, suggests synergism. The potency (Dm) of the combination
of garcinol and curcumin was 2 to 10 fold that of the individual
agents. This indicates that curcumin and garcinol in combination
exhibit a high level of synergism, with enhanced bioactivity,
thereby reducing the required effective dose required for each
individually. This combinatorial strategy may hold promise in
future development of therapies against PaCa.
PMID:22685460 [PubMed] http://www.ncbi.nlm.nih.gov/pubmed/22685460
Free full text article: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366245/
Myricetin induces pancreatic cancer
cell death via the induction of apoptosis and inhibition of the
phosphatidylinositol 3-kinase (PI3K) signaling pathway.
Cancer Lett. 2011 Sep 28;308(2):181-8. Epub 2011 Jun 14.
Phillips PA, Sangwan V, Borja-Cacho D, Dudeja V, Vickers SM,
Saluja AK.
Source: Department of Surgery, University of Minnesota,
Minneapolis, 55455, United States.
Abstract
Pancreatic cancer is the fourth leading cause of cancer related
deaths and is a disease with poor prognosis. It is refractory to
standard chemotherapeutic drugs or to novel treatment
modalities, making it imperative to find new treatments. In this
study, using both primary and metastatic pancreatic cancer cell
lines, we have demonstrated that the flavonoid myricetin induced
pancreatic cancer cell death in vitro via apoptosis, and caused
a decrease in PI3 kinase activity. In vivo, treatment of
orthotopic pancreatic tumors with myricetin resulted in tumor
regression and decreased metastatic spread. Importantly,
myricetin was non-toxic, both in vitro and in vivo, underscoring
its use as a therapeutic agent against pancreatic cancer.
PMID: 21676539
http://www.ncbi.nlm.nih.gov/pubmed/21676539
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Updated: July 25, 2012
Inception: July 25, 2012