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[leukoaraiosis]

Possible cause of common dementia found, opening avenues for treatment
Date: October 30, 2014
Source: University Health Network (UHN)
Summary: A major cause of dementia has been potentially discovered, scientists report. In the type of dementia studied, there is damage to the white matter (nerve fibres) of the brain apparent on computerized tomography (CT) and magnetic resonance imaging (MRI) scans of older individuals… white matter disease (also called leukoaraiosis) may actually be the result of many tiny unnoticed strokes accumulating over time…
http://www.sciencedaily.com/releases/2014/10/141030100521.htm

Journal Reference:

1.John Conklin, Frank L. Silver, David J. Mikulis, Daniel M. Mandell. Are acute infarcts the cause of leukoaraiosis? Brain mapping for 16 consecutive weeks. Annals of Neurology, 2014; DOI: 10.1002/ana.24285

Are acute infarcts the cause of leukoaraiosis? Brain mapping for 16 consecutive weeks.
Ann Neurol. 2014 Oct 4. doi: 10.1002/ana.24285. [Epub ahead of print]
Conklin J1, Silver FL, Mikulis DJ, Mandell DM.
Abstract: Neuroimaging of older adults commonly reveals abnormality (leukoaraiosis) in the cerebral white matter. Studies have established that extensive leukoaraiosis predicts dementia and disability, but the pathogenesis of leukoaraiosis remains unclear. We recruited 5 patients with leukoaraiosis and performed magnetic resonance mapping of the brain for 16 consecutive weeks. We observed tiny lesions arising de novo in the cerebral white matter. These lesions were clinically silent. They had the signature features of acute ischemic stroke. With time, the characteristics of these lesions approached those of pre-existing leukoaraiosis. Together, these findings suggest that tiny silent acute infarcts are a cause of leukoaraiosis. Ann Neurol 2014.
PMID: 25283088  [PubMed]
http://www.ncbi.nlm.nih.gov/pubmed/25283088



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