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"Give
with a free hand, but give only your own."
-- J.R.R.
Tolkien The Children of Hurin
- Multiple Sclerosis (MS) -
General
Information:
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Observations:
The
Multiple Sclerosis and Diet Saga
The
McDougall Newsletter, Vol. 8, No. 1, January 2009
“Our
figures show that at least 95% of people with MS that follow a
low-fat [saturated fat] diet show no progression of disease.”
https://www.drmcdougall.com/misc/2009nl/jan/ms.htm
Here
are some news articles about MS from Science Daily I ran across.
Multiple
Sclerosis Successfully Reversed In Mice: New Immune-Suppressing
Treatment Forces The Disease Into Remission
ScienceDaily
(Aug. 12, 2009) — A new experimental treatment for multiple
sclerosis (MS) completely reverses the devastating autoimmune
disorder in mice, and might work exactly the same way in humans, say
researchers at the Jewish General Hospital Lady Davis Institute for
Medical Research and McGill University in
Montreal...
http://www.sciencedaily.com/releases/2009/08/090811143725.htm
New
Pill To Treat Multiple Sclerosis
ScienceDaily
(Apr. 30, 2009) — A new drug for multiple sclerosis can
dramatically reduce the chances of a relapse or a deterioration of
the condition, according to a new study from researchers at Queen
Mary, University of
London...
http://www.sciencedaily.com/releases/2009/04/090429205613.htm
Little
Pill Means Big News in the Treatment of Multiple
Sclerosis
ScienceDaily
(Jan. 26, 2010) — A new drug for multiple sclerosis promises to
change the lives of the 100,000 people in the UK who have the
condition, say researchers at Queen Mary, University of London. A
major trial of the oral drug Cladribine -- results of which are
published in the New England Journal of Medicine on 20 January 2010
-- has shown that it significantly reduces relapse and deterioration
of the disease, and goes a long way to eliminating the unpleasant
side effects associated with existing therapies. Cladribine promises
to be the first ever treatment in tablet form for MS, and only needs
be taken for between 8 to 10 days a year, eliminating the need for
regular injections and intravenous infusions otherwise endured by
sufferers. The ease with which Cladribine tablets can be
administered, combined with its relatively few side effects, make it
a hugely exciting development in the world of
MS...
http://www.sciencedaily.com/releases/2010/01/100120211016.htm
Inexpensive
Hypertension Drug Could Be Multiple Sclerosis Treatment, Study
Suggests
ScienceDaily
(Aug. 19, 2009) — Turning serendipity into science, researchers
at the Stanford University School of Medicine have found a link, in
mice and in human brain tissue, between high blood pressure and
multiple sclerosis. Their findings suggest that a safe, inexpensive
drug already in wide use for high blood pressure may have therapeutic
value in multiple sclerosis, as well... Next, the investigators
turned to an equally well-established animal model: a laboratory-bred
strain of mouse that, after being immunized with a particular
chemical, develops brain lesions very similar to those observed in
multiple sclerosis. When, before immunization with the
disease-triggering chemical, mice got lisinopril dosages equivalent
to those prescribed for humans with high blood pressure, they didn't
develop the paralysis characteristic of disease progression.
Strikingly, if it was given after the mice developed full-blown
symptoms, lisinopril reversed their
paralysis...
http://www.sciencedaily.com/releases/2009/08/090817184437.htm
Note: lisinopril is available NOW.
Even though it is a blood pressure drug, if it is safe to try, a
physician can prescribe it "off label".
Promising
Therapy for Relapsing Multiple Sclerosis
ScienceDaily
(Feb. 18, 2010) — An international team of researchers has
found that adding a humanized monoclonal antibody called daclizumab
to standard treatment reduces the number of new or enlarged brain
lesions in patients with relapsing multiple sclerosis. This new study
was published online Feb. 16, 2010, and in the March edition of the
Lancet
Neurology...
http://www.sciencedaily.com/releases/2010/02/100216140307.htm
Note: Daclizumab had been available
in Europe. It was used to prevent rejection of transplanted organs,
such as a kidney. Due to low sales volumes, the manufacturer no
longer sells it. Perhaps this will change if it is effective against
MS.
Lipoic
acid: a novel therapeutic approach for multiple sclerosis and other
chronic inflammatory diseases of the CNS.
Salinthone
S, Yadav V, Bourdette DN, Carr DW.
Abstract
The
naturally occurring antioxidant lipoic acid (LA) was first described
as an essential cofactor for the conversion of pyruvate to
Acetyl-CoA, a critical step in respiration. LA is now recognized as a
compound that has many biological functions. Along with its reduced
form dihydrolipoic acid (DHLA), LA reduces and recycles cellular
antioxidants such as glutathione, and chelates zinc, copper and other
transition metal ions in addition to heavy metals. LA can also act as
a scavenger of reactive oxygen and nitrogen species. By acting as an
insulin mimetic agent, LA stimulates glucose uptake in many different
cell types and can also modulate insulin signaling. The p38 and ERK
MAP kinase pathways, AKT and NFkappaB are all regulated by LA. In
addition, LA activates the prostaglandin EP2 and EP4 receptors to
stimulate the production of the small molecule cyclic adenosine 5'
monophosphate (cAMP). These diverse actions suggest that LA may be
therapeutically effective in treating oxidative stress associated
diseases. This review discusses the known biochemical properties of
LA, its antioxidant properties, its ability to modulate signal
transduction pathways, and the recent progress made in the
utilization of LA as a therapeutic alternative for multiple
sclerosis, Alzheimer's disease and diabetic neuropathy.
PMID:
18537699 [PubMed - indexed for
MEDLINE]
http://www.ncbi.nlm.nih.gov/pubmed/18537699
The discovery detailed in the next article may be related to CCSVI.
Multiple
Sclerosis Blocked in Mouse Model: Barring Immune Cells from Brain
Prevents Symptoms
ScienceDaily
(Mar. 7, 2011) — Scientists have blocked harmful immune cells
from entering the brain in mice with a condition similar to multiple
sclerosis
(MS)...
http://www.sciencedaily.com/releases/2011/03/110307103652.htm
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Known
sources:
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Natural
sources:
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References:
[for
MS..]
Preliminary results of the treatment of a mouse model of
Multiple Sclerosis with
Anatabine.
http://www.rfdn.org/ms_anatabine.html
New
Drug Could Treat Alzheimer's, Multiple Sclerosis and Brain
Injury
ScienceDaily
(July 24, 2012) — A new class of drug developed at Northwestern
University Feinberg School of Medicine shows early promise of being a
one-size-fits-all therapy for Alzheimer's disease, Parkinson's
disease, multiple sclerosis and traumatic brain injury by reducing
inflammation in the brain… By addressing brain inflammation,
the new class of drugs -- represented by MW151 and MW189 -- offers an
entirely different therapeutic approach to Alzheimer's than current
ones being tested… MW151 and MW189 work by preventing the
damaging overproduction of brain proteins called proinflammatory
cytokines…
http://www.sciencedaily.com/releases/2012/07/120724171302.htm
http://www.eurekalert.org/pub_releases/2012-07/nu-ndc072312.php
[No
PubMed citation yet]
Reviled
Substance Involved in Alzheimer's Can Reverse Paralysis in Mice With
Multiple Sclerosis
ScienceDaily
(Aug. 1, 2012)
...In mice whose immune systems had been
"trained" to attack myelin, which typically results in
paralysis, A-beta injections delivered before the onset of symptoms
prevented or delayed the onset of paralysis. Even when the injections
were given after the onset of symptoms, they significantly lessened
the severity of, and in some cases reversed, the mice's
paralysis...
http://www.sciencedaily.com/releases/2012/08/120801143717.htm
Reversal
of Paralysis and Reduced Inflammation from Peripheral Administration
of -Amyloid in TH1 and TH17 Versions of Experimental Autoimmune
Encephalomyelitis.
J. L.
Grant, E. E. B. Ghosn, R. C. Axtell, K. Herges, H. F. Kuipers, N. S.
Woodling, K. Andreasson, L. A. Herzenberg, L. A. Herzenberg, L.
Steinman.
Science Translational Medicine, 2012; 4 (145):
145ra105 DOI: 10.1126/scitranslmed.3004145
[NO
PubMed citation yet]
Preliminary
results of the treatment of a mouse model of Multiple Sclerosis with
Anatabine.
http://www.rfdn.org/ms_anatabine.html
Roskamp
Institute Reports Beneficial Effects of Nutritional Supplementation
with Anatabine in an Animal Model of Multiple Sclerosis
Posted
on May 8, 2012 by evan
http://anatabloc.com/tag/multiple-sclerosis/
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Updated: July 2,
2012
Inception: July 2, 2012