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Leukine


See also Infection and the Immune System Response, Inflammation,

Can Leukine Stop or Slow Down Alzheimer's Disease?

Alzheimer's Reading Room
Monday, August 23, 2010
By Bob DeMarco

A signaling protein released during rheumatoid arthritis dramatically reduced Alzheimer's disease pathology and reversed the memory impairment of mice bred to develop symptoms of the neurodegenerative disease, a new study by the University of South Florida reports.

Researchers found that the protein, GM-CSF (Leukine), likely stimulates the body's natural scavenger cells to attack and remove Alzheimer's amyloid deposits in the brain.

The study appeared online in the Journal of Alzheimer's Disease.

People with rheumatoid arthritis, a chronic disease leading to inflammation of joints and surrounding tissue, are less likely than those without arthritis to develop Alzheimer's. While it was commonly assumed that non-steroidal anti-inflammatory drugs may help prevent onset and progression of Alzheimer's disease, recent NSAID clinical trials proved unsuccessful for patients with Alzheimer's...

"Moreover, the recombinant human form of GM-CSF (LeukineŽ) is already approved by the FDA and has been used for years to treat certain cancer patients who need to generate more immune cells," Dr. Potter said. "Our study, along with the drug's track record for safety, suggests Leukine should be tested in humans as a potential treatment for Alzheimer's disease."

http://www.alzheimersreadingroom.com/2010/08/can-leukine-stop-or-slow-down.html


Protein linked to arthritis could help treat Alzheimer's
The Scotsman
Published Date: 23 August 2010
By Lyndsay Moss
http://thescotsman.scotsman.com/news/Protein-linked-to-arthritis-could.6488309.jp?articlepage=1

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Updated: July 2, 2012
Inception: July 2, 2012