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Globulomer -

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Dr. Ray Shahelien entry: 


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Understanding Alzheimer’s Disease

"Abbott’s Discovery

Abbott neuroscientists presented data on their discovery of a new soluble and globular form of the amyloid ß-peptide, which they have termed globulomer. They also demonstrated that these globulomers are indeed present in the brains of patients with Alzheimer’s, that they selectively bind to nerve cells in the hippocampus area of brain, and that they disrupt learning and memory. These findings, while very early, could lead to drug candidates that selectively target these globulomers and stop progression of the disease."

[Link no longer available from Abbott]
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Globular amyloid beta-peptide oligomer - a homogenous and stable
neuropathological protein in Alzheimer's disease.

Barghorn S, Nimmrich V, Striebinger A, Krantz C, Keller P, Janson B, Bahr
M, Schmidt M, Bitner RS, Harlan J, Barlow E, Ebert U, Hillen H

Neuroscience Discovery Research, Abbott GmbH and Co. KG, Ludwigshafen,

Amyloid beta-peptide (Abeta)(1-42) oligomers have recently been discussed as intermediate toxic species in Alzheimer's disease (AD) pathology. Here we describe a new and highly stable Abeta(1-42) oligomer species which can easily be prepared in vitro and is present in the brains of patients with AD and Abeta(1-42)-overproducing transgenic mice.

Amyloid Oligomers—Not So Elusive, After All? Part 1

6 December 2005. "For the past decade, Alzheimer researchers have gradually built the argument that small species of the amyloid-β peptide might be harming neurons in ways quite separate from the damage done by fibrillized forms. In short, their slogan is, “It’s Not the Plaques, Stupid!”

Abbott Finds New Amyloid in Alzheimer’s 11/16/05

"Among the hallmarks of Alzheimer’s, which include neurofibrillary tangles and amyloid plaques, Abbott Laboratories Inc., Abbott Park, Ill., researchers now say they found a new species of amyloid beta-peptide that selectively binds to nerve cells in the brain and is an important causal factor for the disease."
“For years researchers have focused on finding ways to stop the formation of the plaque, believing that the plaques themselves were toxic,” says James Sullivan, PhD, vice president, neuroscience discovery, Abbott. “Over the last five years, however, more and more research suggests that we did not have the whole story.”

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Updated: July 25, 2012
Inception: July 25, 2012