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- Genetics -
General Information:
Names:
Wikipedia entry:
Dr. Ray Shahelien entry:
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Observations:
Genetics
See also Mitochondrial
Dysfunction
More Evidence That Alzheimer's Disease May Be Inherited from
Your Mother
ScienceDaily
(Feb.
28, 2011) — Results from a new study contribute to growing
evidence that if one of your parents has Alzheimer's disease,
the chances of inheriting it from your mother are higher than
from your father. The study is published in the March 1, 2011,
print issue of Neurology®, the medical journal of the American
Academy of Neurology... The researchers found that people with a
mother who had Alzheimer's disease had twice as much gray matter
shrinkage as the groups who had a father or no parent with
Alzheimer's disease. In addition, those who had a mother with
Alzheimer's disease had about one and a half times more whole
brain shrinkage per year compared to those who had a father with
the disease. Shrinking of the brain, or brain atrophy, occurs in
Alzheimer's disease...
http://www.sciencedaily.com/releases/2011/02/110228163026.htm
Cell loss
was especially pronounced in two areas of the brain: the left
precuneus (which plays a role in episodic memory, among other
functions) and the left parahippocampas gyrus (which is involved
in encoding and retrieving memories).
Other
regions that took a hit were "the anterior cingulate, the
bilateral middle temporal gyrus, the right hippocampus, right
precuneus and posterior cingulate," according to a study in the
March 1 edition of the journal Neurology.
Progressive regional atrophy
in normal adults with a maternal history of Alzheimer disease.
Neurology.
2011 Mar 1;76(9):822-9.
Honea
RA, Swerdlow RH, Vidoni ED, Burns JM.
Department of Neurology, University of Kansas School of
Medicine, 2100 West 36th Ave., Suite 110, Kansas City, KS 66160
rhonea@kumc.edu.
Abstract
OBJECTIVE: Beyond age, having a family history is the most
significant risk factor for Alzheimer disease (AD). This
longitudinal brain imaging study examines whether there are
differential patterns of regional gray matter atrophy in
cognitively healthy elderly subjects with (FH+) and without
(FH-) a family history of late-onset AD.
METHODS: As part of the KU Brain Aging Project, cognitively
intact individuals with a maternal history (FHm, n = 11),
paternal history (FHp, n = 10), or no parental history of AD
(FH-, n = 32) similar in age, gender, education, and Mini-Mental
State Examination (MMSE) score received MRI at baseline and
2-year follow-up. A custom voxel-based morphometry processing
stream was used to examine regional differences in atrophy
between FH groups, controlling for age, gender, and APOE ε4
(APOE4) status. We also analyzed APOE4-related atrophy.
RESULTS: Cognitively normal FH+ individuals had significantly
increased whole-brain gray matter atrophy and CSF expansion
compared to FH-. When FH+ groups were split, only FHm was
associated with longitudinal measures of brain change. Moreover,
our voxel-based analysis revealed that FHm subjects had
significantly greater atrophy in the precuneus and
parahippocampus/hippocampus regions compared to FH- and FHp
subjects, independent of APOE4 status, gender, and age.
Individuals with an ε4 allele had more regional atrophy in the
frontal cortex compared to ε4 noncarriers.
CONCLUSIONS: We conclude that FHm individuals without dementia
have progressive gray matter volume reductions in select
AD-vulnerable brain regions, specifically the precuneus and
parahippocampal gyrus. These data complement and extend reports
of regional cerebral metabolic differences and increases in
amyloid-β burden in FHm subjects, which may be related to a
higher risk for developing AD.
PMID: 21357834 [PubMed]
http://www.ncbi.nlm.nih.gov/pubmed/21357834
If your mother has
Alzheimer's, you are at greater risk: Study
By Karen Kaplan, Los Angeles Times March 1, 2011
http://www.canada.com/health/Study+your+mother+Alzheimer+greater+risk/4361784/story.html
Since we
inherit the mitochondria exclusively from our mothers, not our
fathers, the ideas associated with "mitochondrial dysfunction"
seem more compelling.
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Known sources:
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Natural sources:
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References:
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Updated: July 2, 2012
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