"Give with a free hand, but give only your own."
 -- J.R.R. Tolkien The Children of Hurin
- Davunetide -

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See also Tau Busters

NOTE:  Davunetide was reported to have failed a clinical trial for PSP in 2012

A message was posted on another message board I frequent about a drug called davunetide. It is a press release from a company called Allon Therapeutics Inc. about another potential tau-buster drug they call "davunetide intranasal" (AL-108). They are conducting a clinical trial for a tauopathy FTD called PSP (progressive supranuclear palsy).

If the reason that Rember appeared to be effective was because of its effect on the Helicobacter pylori (and the resulting reduction in TNF), not on its ability to "prevent tau aggregation and disaggregate aggregations already formed", then I expect the results of the AL-108 clinical trial will be disappointing.

However, if it does pan out, then this will support the rationale for attacking the tau problem.

So, now we have 5 potential tau-busters: cinnamon proanthocyanidins, methylene blue, niacinamide, grape seed extract, and davunetide. Anyone who holds the opinion that davunetide has the potential to be effective because of its effect on the tau protein problem of tauopathies should also be encouraged to know that the other potential tau-busters are MUCH easier to obtain than davunetide.

Pilot Clinical Trial Meets Primary Endpoint With Allon's Davunetide
Medical News Today
Article Date: 11 Oct 2010 - 3:00 PDT

Allon Therapeutics Inc. (TSX: NPC) announced that a pilot clinical trial successfully met its primary endpoint of safety and tolerability, with the Company's lead neuroprotective drug candidate davunetide, in patients with progressive supranuclear palsy (PSP) and other types of frontotemporal dementia (FTD) like corticobasal syndrome, and progressive non-fluent aphasia. FTD is a group of rapidly progressive and fatal degenerative brain diseases, often misdiagnosed as Parkinson's or Alzheimer's disease... Allon's laboratory and animal studies have shown that davunetide improves cognition in a number of disease models through a mechanism believed to involve effects on microtubules, structures in the brain critical to communication between cells...

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Updated: July 2, 2012
Inception: July 2, 2012