"Give with a free hand, but give only your own."
 -- J.R.R. Tolkien The Children of Hurin
- Clioquinol -

General Information:

Wikipedia entry:
Dr. Ray Shahelien entry: 



  - An old drug with new possibilities

[I wonder if clioquinol is effective against Helicobacter pylori?]

Known sources:

Natural sources:


Clioquinol:  metal chelator
A[beta] Metallobiology and the Development of Novel Metal-Protein Attenuating
Compounds (MPACs) for Alzheimer's Disease
Cyril C. Curtain1, Kevin J. Barnham1 and Ashley I. Bush

"Abstract: Over a decade of studies have pointed to metal mediated neural oxidative damage asan attractive target for the treatment of Alzheimer’s disease. Because of the nature of the blood brain barrier, systemic depletion of the metals, copper, zinc and possibly iron, is not a viable approach. However preliminary studies with CQ, a blood brain barrier penetrating chelating agent, are showing promise. CQ probably works by combining with the metal centres, primarily copper and zinc complexes of Ab, in the neuropil. This review discusses some of the background that resulted in CQ becoming a lead compound and how we might advance our understanding of its action"

PBT2 Demonstrates Rapid And Potent Effects In Cognition, Reduction Of Brain Soluble Beta-amyloid And Significant Improvement In Synaptic Function
20 Jul 2006
The observation that PBT1 (clioquinol)[2], a retired anti-amoebic drug, could halt cognitive decline in a pilot Phase IIa Alzheimer's patient study was the original catalyst for the creation of Prana's new generation MPAC (Metal Protein Attenuating Compound) chemical library. This platform of agents may have therapeutic utility in several key neurological disorders. Rodent pharmacokinetic studies have shown that the brain concentration of PBT2 is about 50-fold greater than clioquinol for an IV equivalent dose...

Treating protein folding diseases
"Preventing aggregation is therefore a primary therapeutic target, but there is more than one stage that can be targeted. Strategies so far have focused on disrupting polymerization and fibril aggregation. These include using low-molecular-weight substances such as congo red dye, the antibiotic rifampicin, peptides that bind to amyloid-b  peptide and drugs that chelate metals such as copper and zinc, which themselves accelerate amyloid-b deposition. Indeed, interim results from a placebo-controlled trial of the antibiotic iodochlorhydroxyquin (Clioquinol), which chelates these metals in vitro, showed slowing of cognitive decline in the most severely affected of 32 Alzheimer's disease patients studied."




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Updated: July 2, 2012
Inception: July 2, 2012