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- C-reactive protein (CRP)
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UCSF Study Links Inflammation in Brain to Some Memory Decline
Source: Jennifer O'Brien
University of California, San Francisco
April 13, 2011

High levels of a protein associated with chronic, low-grade inflammation in the brain correlate with aspects of memory decline in otherwise cognitively normal older adults, according to a study led by scientists at the University of California, San Francisco.

The study is being reported in a poster session at the American Academy of Neurology annual meeting on Wednesday, April 13, 2011.

Inflammation is part of the body’s natural immune response to tissue damage. However, chronic inflammation is associated with many diseases. In the brain, it is thought to play a role in aging and neurodegenerative diseases, such as Parkinson’s and Alzheimer’s. If further research determines that inflammation causes memory decline, anti-inflammatory drugs could prove useful in staving off the damage.

Studies in animals have shown that prolonged brain inflammation impairs function of the hippocampus, a region of the brain involved in storing and generating memory. It does so by disrupting the establishment of memories, a process known as long term potentiation.

The scientists in the study hypothesized that the presence of C-reactive protein (CRP), a marker of chronic low grade inflammation in the brain, would be associated with poorer memory creation and smaller medial-temporal lobes, which include the hippocampus...
http://www.ucsf.edu/news/2011/04/9712/ucsf-study-links-inflammation-brain-some-memory-decline


Study Links Inflammation in Brain to Some Memory Decline

ScienceDaily (Apr. 15, 2011)
http://www.sciencedaily.com/releases/2011/04/110413151645.htm

C-Reactive Protein
Definition

C-reactive protein is produced by the liver. The level of CRP rises when there is inflammation throughout the body.

This article discusses the blood test done to measures the amount of CRP in your blood...
http://www.ucsfhealth.org/tests/003356.html

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Updated: July 2, 2012
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