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- COGNIShunt -
General Information:
Names:
Wikipedia entry:
Dr. Ray Shahelien entry:
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Observations:
An interesting question would be, what happens to the amyloid beta if scyllitol dissolves it? Imagine a jar full of paint thinner. Dip your paintbrush into the jar, and the paint comes off the brush, but it's now dissolved in the paint thinner. If the paint thinner evaporates, the once dissolved paint coats the bottom of the jar. Perhaps if scyllitol dissolves amyloid beta plaques, then a device such as the COGNIshunt would be needed to clear out the contaminated fluid.
However, the company that was developing the COGNIShunt, Eunoe, Inc. "ceased operations" in 2005. I guess this means they went out of business. A company called Integra LifeSciences bought the "intellectual property" of Eunoe, Inc. But in Integra's December 31, 2006 Annual Report they seem to claim the cost of this aquisition as a loss:
"In September 2005, we acquired the intellectual property estate of Eunoe, Inc. for $0.5 million in cash. Prior to ceasing operations, Eunoe, Inc. was engaged in the development of its innovative COGNIShunt® system for the treatment of Alzheimer’s disease patients. The acquired intellectual property has not been developed into a product that has been approved or cleared by the FDA and has no future alternative use other than in clinical applications involving the regulation of cerebrospinal fluid. Accordingly, we recorded the entire acquisition price as an in-process research and development charge in 2005."
Hmmm. Too bad. Seemed like a promising idea. Was there any real science behind this? Or was this some sort of bad joke on us all in order to perpetuate some sort of investment scam? I hope not.
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Known sources:
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Natural sources:
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References:
COGNIShunt
From the Intregra LifeSciences annual report for the fiscal year
ended December 31, 2006
"In September 2005, we acquired the intellectual property estate
of Eunoe, Inc. for $0.5 million in cash. Prior to ceasing
operations, Eunoe, Inc. was engaged in the development of its
innovative COGNIShunt® system for the treatment of Alzheimer’s
disease patients. The acquired intellectual property has not
been developed into a product that has been approved or cleared
by the FDA and has no future alternative use other than in
clinical applications involving the regulation of cerebrospinal
fluid. Accordingly, we recorded the entire acquisition price as
an in-process research and development charge in 2005."
http://apps.shareholder.com/sec/viewerContent.aspx?companyid=IART&docid=5005174
Alzheimer's Breakthrough Could
Halt Disease
New Procedure May Even Reverse Symptoms
10:46 a.m. PST November 19, 2003
UPDATED: 11:32 a.m. PST November 19, 2003
LOS ANGELES -- A new procedure may be the first to halt the
progression of Alzheimer's disease -- it may even reverse
symptoms.
We hear so much about Alzheimer's treatments, all of which have
failed to pan out -- until now. The new procedure involves the
COGNIShunt® Device and it may be the first to actually help
treat the disease.
Norma Thaier's doctor recently told her she was in the early
stages of Alzheimer's disease. "This is a terrible disease. It
steals your mind," said Thaier, whose symptoms are mild now.
Thaier's symptoms may never get worse, thanks to the
COGNIShunt®.
"I think I was lucky to get into this study," said Thaier.
Researchers implanted the tiny shunt in Thaier's brain nine
months ago.
Dr. George Grossberg said the treatment continually draws a
small amount of spinal fluid off the brain, and that may prevent
the damage thought to cause the symptoms of Alzheimer's.
"What's special and unique about the COGNIShunt®, is that it's
almost like a circulatory device," explained Grossberg.
http://virtuallawoffice.com/eve/forums/a/tpc/f/2676030044/m/7576055394/r/3531064002
Drugs In Clinical Trials
Development Status: investigational
FDA Phase: Phase II/IIa/IIb
Primary Medical Role: COGNIShunt® System is a
cerebrospinal fluid shunt similar but not identical to shunts
used for the treatment of children and adults with
hydrocephalus. The COGNIShunt® has been engineered specifically
to provide a low flow of cerebrospinal fluid (CSF) in
individuals without hydrocephalus and is designed to improve CSF
clearance without the over drainage of CSF.
Role in Alzheimer's Disease: Cerebrospinal fluid
production and turnover diminish with age and may be further
diminished in Alzheimer's disease. Flow-regulated drainage of
CSF drainage may reduce the accumulation of proteins such as tau
and β-amyloid and other inflammatory mediators implicated in AD.
http://www.alzforum.org/drg/drc/detail.asp?id=98
Emory Studies COGNIShunt Device For Alzheimer's Treatment
Neurologists at Emory University are studying a possible new
treatment for Alzheimer's disease using a device called the
COGNIShunt, designed to drain cerebrospinal fluid (CSF) from the
skull and into the abdominal cavity. By reducing the build-up of
CSF around the brain, doctors hope this device will help to
stabilize the disease.
http://www.sciencedaily.com/releases/2002/03/020327073547.htm
COGNIShunt® System for Alzheimer's Disease
This study has been completed.
Sponsored by: Eunoe
Information provided by: National Institute on Aging (NIA)
ClinicalTrials.gov Identifier: NCT00056628
Purpose
This is a study of the effect on the progression of Alzheimer's
Disease of a surgically implanted shunt (tube) to increase the
flow of cerebrospinal fluid and improve the clearance of
potential neurotoxins from the fluid bathing the brain.
http://www.clinicaltrials.gov/ct/show/NCT00056628
Google search on "COGNIShunt"
http://www.google.com/search?hl=en&lr=&q=COGNIShunt&btnG=Search
About COGNIShunt and Alzheimer’s diseaseFile Format: PDF/Adobe
Acrobat
COGNIShunt is similar to the shunt used to treat hydrocephalus,
a ...
COGNIShunt is not commercially available for sale or
distribution. ...
http://www.trepan.com/pdfs/shunt.pdf
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Updated: July 25, 2012
Inception: July 25, 2012