"Give with a free hand, but give only your own."
 -- J.R.R. Tolkien The Children of Hurin
- Bexarotene -

General Information:

Wikipedia entry:
Dr. Ray Shahelien entry: 



Drug Quickly Reverses Alzheimer's Symptoms in Mice
ScienceDaily (Feb. 9, 2012) — Neuroscientists at Case Western Reserve University School of Medicine have made a dramatic breakthrough in their efforts to find a cure for Alzheimer's disease. The researchers' findings, published in the journal Science, show that use of a drug in mice appears to quickly reverse the pathological, cognitive and memory deficits caused by the onset of Alzheimer's. The results point to the significant potential that the medication, bexarotene, has to help the roughly 5.4 million Americans suffering from the progressive brain disease...

ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models.

Paige E. Cramer, John R. Cirrito, Daniel W. Wesson, C. Y. Daniel Lee, J. Colleen Karlo, Adriana E. Zinn, Brad T. Casali, Jessica L. Restivo, Whitney D. Goebel, Michael J. James, Kurt R. Brunden, Donald A. Wilson, and Gary E. Landreth.
Science, 9 February 2012 DOI: 10.1126/science.1217697


Alzheimer's disease is associated with impaired clearance of β-amyloid from the brain, a process normally facilitated by apolipoprotein E (ApoE). ApoE expression is transcriptionally induced through the action of the nuclear receptors peroxisome proliferator activated receptor (PPARγ) and liver X receptors (LXR) in coordination with retinoid X receptors (RXR). Oral administration of the RXR agonist, bexarotene, to a murine model of Alzheimer's disease resulted in enhanced clearance of soluble Aβ within hours in an apoE-dependent manner. Aβ plaque area was reduced >50% within just 72 hours. Furthermore, bexarotene stimulated the rapid reversal of cognitive, social, and olfactory deficits and improved neural circuit function. Thus, RXR activation stimulates physiological Aβ clearance mechanisms, resulting in the very rapid reversal of a broad range of Aβ-induced deficits.

Bexarotene (tradenamed Targretin) is an oral antineoplastic agent indicated by the FDA (in 2000) for cutaneous T cell lymphoma.[1] It has been used off-label for lung cancer,[2] breast cancer, and Kaposi's sarcoma.

The article pans the idea...

Alzheimer's treatment not the hoped for miracle
8 Aug 2012 5:24pm, EDT
Vitals on NBCNews.com

...Two papers out Wednesday in the New England Journal of Medicine warn families of Alzheimer’s victims not to seek treatment with Targretin (generic name: bexarotene)...

It's noteworthy how "responsible media" publishes articles like this, but don't see the need to include references.  If there are "two papers", well... what are the titles, authors, and where were they published?

Known sources:

Natural sources:





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Updated: July 2, 2012
Inception: July 2, 2012