5-Lipoxygenase Inhibitors

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- 5-Lipoxygenase Inhibitors -

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Observations:

5-lipoxygenase protein modulates amyloid beta formation linked to Alzheimer's disease
18. November 2010 01:36

A protein known to exist in the brain for more than 30 years, called 5-lipoxygenase, has been found to play a regulatory role in the formation of the amyloid beta in the brain, the major component of plaques implicated in the development of Alzheimer's disease, according to researchers at Temple University's School of Medicine.

The researchers also found that inhibitors of this protein currently used to control asthma could possibly be used to prevent or treat Alzheimer's disease... "What we found was 5-lipoxygenase regulates and controls the amount of total amyloid beta produced in the brain. With aging, the more 5-lipoxygenase you have the more amyloid beta you're going to produce. This will translate into a higher risk to develop full Alzheimer's."... He said that there are several FDA-approved 5-lipoxygenase inhibitors currently being used for the treatment of asthma, and that the Temple researchers tested some of these inhibitors in the lab against the production of amyloid beat with initial positive results...
http://www.news-medical.net/news/20101118/5-lipoxygenase-protein-modulates-amyloid-beta-formation-linked-to-Alzheimers-disease.aspx

Asthma medication may have potential as Alzheimer's treatment
Posted November 23, 2010 11:17 AM to the Alzheimer Association message board
"Medications/Treatments for Alzheimer's and Other Related Dementias"
by Billstrailrunning

The potential exciting news is that asthma drugs have been to developed to block this enzyme for the treatment of asthma and are FDA-approved for this indication. Zileuton is the only drug in the US that actually may block this enzyme directly. This drug used to be taken every 6 hours, but now there is a 12 hours dose. The downside is this drug can interact with other drugs and may increase liver enzmes.

Other options might be Singulair or Accolate which are drugs that block leukotriene receptors.

The issue is what dose might be needed to get enough of these drugs past the blood-brain barrier to get a level in the central nervous system to have an effect. The standard dose might not do it...
http://alzheimers.infopop.cc/eve/forums/a/tpc/f/762104261/m/7694060087?r=7694060087#7694060087

Posted November 28, 2010 10:59 PM
by Ranwah

Boswellia serrata plant contains several substances that are 5-LOX inhibitors, there is also an extract of the most active elements and it's under the name 5-loxin. Similar to curcumin Boswellia also has some bio-availability issues.
http://alzheimers.infopop.cc/eve/forums/a/tpc/f/762104261/m/7694060087?r=1564035087#1564035087

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