"Give with a free hand, but give only your own."
-- J.R.R. Tolkien The
Children of Hurin
In my searches through the backwaters of the Internet, I have
run across some interesting ideas that I present here for your
consideration. Research everything thoroughly and discuss
things with your physicians.
Check out the combination of curcumin and standard chemotherapy
or steroid therapy.
Research "ketogenic diets" along with
curcumin and standard therapies. Cancer cells crave sugar,
glucose to be specific, but the rest of the cells in your body
can use "ketone bodies" if glucose is not available. So
the idea is to starve the cancer cells by restricting
carbohydrate and protein calories while allowing
ketone-generating foods. The idea is to attack the cancer on
multiple fronts, not to replace standard therapies, but rather
to make them more effective.
of brain cancer.
Acta. 2010 Sep 8.
TN, Kiebish MA, Marsh J, Shelton LM, Huysentruyt LC, Mukherjee
tumors are a significant health problem in children and
adults. Conventional therapeutic approaches have been largely
unsuccessful in providing long-term management. As primarily a
metabolic disease, malignant brain cancer can be managed
through changes in metabolic environment. In contrast to
normal neurons and glia, which readily transition to ketone
bodies (β-hydroxybutyrate) for energy under reduced glucose,
malignant brain tumors are strongly dependent on glycolysis
for energy. The transition from glucose to ketone bodies as a
major energy source is an evolutionary conserved adaptation to
food deprivation that permits the survival of normal cells
during extreme shifts in nutritional environment. Only those cells with a flexible
genome and normal mitochondria can effectively transition
from one energy state to another. Mutations restrict
genomic and metabolic flexibility thus making tumor cells more
vulnerable to energy stress than normal cells. We propose an
alternative approach to brain cancer management that exploits
the metabolic flexibility of normal cells at the expense of
the genetically defective and metabolically challenged tumor
cells. This approach to brain cancer management is supported
from recent studies in mice and humans treated with calorie
restriction and the ketogenic diet. Issues of implementation
and use protocols are presented for the metabolic management
of brain cancer.
Fasting Cycles Retard Growth
of Tumors and Sensitize a Range of Cancer Cell Types to
Changhan Lee, Lizzia Raffaghello, Sebastian Brandhorst,
Fernando M. Safdie, Giovanna Bianchi, Alejandro
Martin-Montalvo, Vito Pistoia, Min Wei, Saewon Hwang, Annalisa
Merlino, Laura Emionite, Rafael de Cabo, and Valter D. Longo.
Science Translational Medicine, Feb 8, 2012 DOI:
Short-term starvation (or fasting) protects normal cells,
mice, and potentially humans from the harmful side effects of
a variety of chemotherapy drugs. Here we show that treatment
with starvation conditions sensitized yeast cells (S.
cerevisiae) expressing the oncogene-like RAS2val19 to
oxidative stress and 15 of 17 mammalian cancer cell lines to
chemotherapeutic agents. Cycles of starvation (fasting) were
as effective as chemotherapeutic agents in delaying
progression of specific tumors and increased the effectiveness
of these drugs against melanoma, glioma, and breast cancer
cells. In mouse models of neuroblastoma, fasting cycles plus
chemotherapy drugs—but not either treatment alone—resulted in
long-term cancer-free survival. In 4T1 breast cancer cells,
short-term starvation resulted in increased phosphorylation of
the stress-sensitizing AKT and S6 kinases, increased oxidative
stress, caspase-3 cleavage, DNA damage and apoptosis. These
studies suggest that multiple cycles of fasting promote
differential stress sensitization in a wide range of tumors
and could potentially replace or augment the efficacy of
certain toxic chemotherapy drugs in the treatment of various
Fasting Weakens Cancer in
ScienceDaily (Feb. 8, 2012) — ...a study that found
chemotherapy drugs work better when combined with cycles of
short, severe fasting... For example, multiple cycles of
fasting combined with chemotherapy cured 20 percent of mice
with a highly aggressive type of children's cancer that had
spread throughout the organism and 40 percent of mice with a
more limited spread of the same cancer...
Angelo John appears in the October 2001 issue (Volume 57,
Number 4) pages 429-431 of the prestigious journal Medical
...It has been well established that caloric restriction in
the daily diet reduces tumor size in laboratory animals.
Kritchevsky's studies with rats show that just a ten percent
caloric restriction reduced tumor size and that a forty
percent caloric restriction caused tumors to disappear
completely. (l5) I contend one reason that
caloric restriction results in tumor shrinkage is that it
contributes to the increase of ketones in the blood. This in
turn inhibits the activity of phosphofructokinase an enzyme
that plays a key role in the regulation of glycolysis...
"Ketogenic diets" are well established
for treating medication-resistant epilepsy. Such a diet is
apparently tough to follow and needs supervision of a medical
professional experienced with it, but it can be done. Here
is an example:
Friends Dietary Treatments for Epilepsy
Some interesting "natural medicines" (substances produced by
green plants instead of pharmaceutical plants)
Diet: Another interesting idea from the fringes
is the Budwig
Diet, which consists essentially of flaxseed oil and
cottage cheese. As I understand it, the cottage cheese
just makes the flaxseed oil more available. "...daily
about 4 oz. of cottage cheese mixed well with 1.5 oz. of linseed
oil and 1 oz. of milk..." Just do a search for in using
your favorite search engine. It's all over the Internet.
tea and its major constituent epigallocatechin gallate
(EGCG) prevents cancer cells from
growing by binding to an enzyme called "dihydrofolate
of the curry spice turmeric is actively being studied for its
ability to inhibit several types of cancer. It appears to
be especially effective with cats and dogs since their livers do
not break down curcumin as quickly as the human liver.
However, if one takes piperine (a chemical found in black
pepper) at the same time as curcumin, the liver will be
prevented from breaking it down for a couple of hours.
This might give it time to be more effective. However,
piperine might interfere with other drugs that need the liver to
be effective. There might be a "window of time" in one's
day that will allow for the use of curcumin/piperine.
Curcumin with piperine is available from well-stocked health
food stores or online. It is sold as an anti-inflammatory
for people with arthritis. This is not a replacement for
standard therapies, but as an adjunct to attack the disease from
a different angle.
So, do what the physicians say, go through "standard therapies",
but if you find something like some of the above that don't
conflict with the physician's programs, and if they don't cost
too much, why not gamble a few bucks?
Myricetin induces pancreatic
cancer cell death via the induction of apoptosis and
inhibition of the phosphatidylinositol 3-kinase (PI3K)
Cancer Lett. 2011 Sep 28;308(2):181-8. Epub 2011 Jun 14.
Phillips PA, Sangwan V, Borja-Cacho D, Dudeja V, Vickers SM,
Source: Department of Surgery, University of Minnesota,
Minneapolis, 55455, United States.
Pancreatic cancer is the fourth leading cause of cancer related
deaths and is a disease with poor prognosis. It is refractory to
standard chemotherapeutic drugs or to novel treatment
modalities, making it imperative to find new treatments. In this
study, using both primary and metastatic pancreatic cancer cell
lines, we have demonstrated that the flavonoid myricetin induced
pancreatic cancer cell death in vitro via apoptosis, and caused
a decrease in PI3 kinase activity. In vivo, treatment of
orthotopic pancreatic tumors with myricetin resulted in tumor
regression and decreased metastatic spread. Importantly,
myricetin was non-toxic, both in vitro and in vivo, underscoring
its use as a therapeutic agent against pancreatic cancer.
Research soaking the nails apple cider
Urinary Tract Infections (UTI)
Research applying Vic's Vapo Rub
Research using cranberry juice
Research using Alka-Selzer
(Just as prescribed on the box!)
Research the "Jump and Bump" method, or
modifications of it. This is a purely mechanical technique
that will hopefully use the "water hammer" effect to drive out a
stone. Basically, it goes like this. At the first
sign of kidney stone pain, start drinking 2 to 2-1/2 pints of
water in 20 minutes. Then, while leaning on a window sill
or other convenient surface to put your back at a 45 degree
angle, rise up on your toes and come down hard on your heels
several times. This may move the stone down the
ureter. Do this every 5 minutes, and pee in between
"jump". A stone at the entrance to the bladder is more
likely to enter the bladder when it is emptying.
As far as I know, calcium oxalate kidney stones (the most common
type), are basically rocks. I am not aware of anything
that will dissolve them (unlike the less common uric acid
stones). However, some people swear by the "Coke and
Research Coke and asparagus.
Drink 6 cans of Coke in 2 hrs, followed by eating 1/2 can of
asparagus. Some say diet Coke and caffeine free Coke
work just as well. The asparagus is used as a diuretic.
I can't say if this really works or not, but in desperation one
time, after suffering with a rather large stone at the UVJ (the
place where the ureter enters the bladder) for several weeks, I
tried drinking 6 cans of Coke and eating a can of
asparagus. Even though I love Coke, and I'm fond of
asparagus too, 6 cans in 2 hours followed by a can of asparagus
did a number on my stomach. Nothing happened. At
least to the stone.
The next weekend, I tried it again. After finishing the
last Coke (this time I used caffeine-free Coke), out popped one
big nyucker of a spiny calcium oxalate stone. OUCH!
I didn't even get to the asparagus. So, did the Coke do
the trick? Well, it didn't dissolve or break up the stone,
but maybe it causes the urinary tract to get slick, or the
urine, or maybe make it more viscus. I don't know, but it
seems to me that drinking a few cans of Coke might not be too
big of a gamble.
On to some more "scientific" ideas. Some researchers from
Harvard are said to have published a paper in the Journal of
Urology in 1974 stating that adding (at least?) 300mg of
magnesium oxide and 10mg of vitamin B6 will reduce the risk of
recurrent calcium oxalate stones by 92.3% I found a
reference to a 1967 paper in The America Journal of Clinical
Nutrition that does indeed back up this idea (See citation
In 1991, another study was published in the British Journal of
Urology about a 5-year study that found taking about 1
tablespoon (10g) of rice bran twice daily after meals would
reduce calcium oxalate kidney stone formation by 83.4%.
The rice bran idea sort of makes sense. Brans in general
(from grains) are high in phytic
acid. This stuff is such a strong chelator of
minerals that in poor countries where people eat a lot of
unrefined grains, they sometimes become malnourished because the
phytic acid depletes the minerals from their food. Calcium
is a mineral that phytic acid likes to mop up. But, while
I wouldn't mind getting rid of excess minerals in my system, I
don't want to get rid of them all. So, maybe a mere 2
tablespoons per day wouldn't be so bad. I suppose other
"brans" would work too, if they are high in phytic acid.
I followed up on all of the above two ideas a bit and confirmed
the "research" cited. If the research turns out to be
bogus, well, little harm will be done. Even so,
adding B6 and magnesium seems like a pretty safe gamble to take
in the mean time. Rice bran, on the other hand, is a bit
hard to find these days. I remember seeing it at my local
health food store, but the last time I checked (2010), they no
longer carried it. I do remember that it was a bit pricey.
I have also read, and even been told by my urologist, that many
times, chronic calcium oxalate stone formers just simply eat too
much salt. So, adopting a low salt diet may be enough to
end the days of human rock quarry.
Another culprit may be excessive animal protein in the
diet. I said excessive.
That means cutting back, not cutting out.
So, for those of us who are diagnosed with "idopathic urolithiasis" (i.e.
"you're forming kidney stones and we don't know why") of the
calcium oxalate variety, if we add 300mg of magnesium oxide,
10mg of vitamin B6, 20g of rice bran, adopt a standard low-salt,
low animal protein diet that seems to be all the rage these days
(although personally, I don't think food without salt has much
flavor), maybe us human rock quarries could get some
relief. These things aren't expensive to try, and maybe
even more healthy in other ways.
Here are some references:
of daily MgO and vitamin B6 administration to patients with
recurring calcium oxalate kidney stones.
Clin Nutr. 1967 May;20(5):393-9.
SN, Prien EL.
...Patients with histories of recurring calcium oxalate renal
stone formation have been given daily oral supplements of 200 mg of MgO
[magnesium oxide] and 10 mg of pyridoxine [vitamin B6]
for extended periods of time. Thirty of 36 patients maintained
on this program for 5 years or more have shown no recurrence
or decreased recurrence of stone formation. After 1 year on
this regimen, urines obtained from 51 patients showed a marked
increase in their capacity to maintain calcium oxalate in
solution, significantly raised calcium and citric acid levels,
and decreased xanthurenic acid levels. No significant changes
were observed in urinary magnesium, oxalic acid, phosphate-P
or pyrophosphate-P values. Decreases in serum f3-lipoproteins
were also observed in a group of 25 of these subjects...
PMID: 6023850 [PubMed]
This article by Gershoff and Prien also mention some research
showing "a reduction in a dramatic clinical improvement in many
cases of coronary heart disease":
MALKIIL-SHAPIRO, B., AND I. BERSOHN.
Parenteral magnesium sulfate therapy in
coronary heart disease.
Med. Proc. 2: 455, 1956.
More articles on kidney stones:
Eye Infections [The
results of conservative treatment of oxalate urolithiasis in
Merkur Lekarski. 2003 Jul;15(85):51-4.
A, Tkaczyk M, Bilińska W, Nowicki M.
i Dializoterapii Instytutu Centrum Zdrowia Matki Polki w
for 15% of recurrent urolithiasis. There have been only a few
reports on the prevalence and treatment of oxalate
urolithiasis in children.
AIM: Of the study was to assess the efficacy and safety of the
protocol of intensive and combined treatment of hyperoxaluria
AND METHODS: Seventeen children at the mean age of 11.5 +/-
4.5 years with positive history of urolithiasis and diagnosis
of hyperoxaluria were studied. In this group hyperoxaluria was
an isolated defect in 9 of 17 children, but in 3/17 it was
accompanied by hyperuricosuria, in 5/17 by hypomagnesuria and
in 1 case by hypercalciuria. During the 12-month period the
children were intensively hydrated and received a low-oxalate
diet and supplemental therapy with vitamin B6, magnesium,
citrates and lactic acid bacteria preparations.
In all but one child oxaluria decreased below 0.45 mmol/1.73
m2/day (decrease by 45%). No new stone formation was seen
during the observation period. In all patients abdominal pain and
conclude that the intensive, complex, conservative treatment
of hyperoxaluria in children is effective and safe. It allows
to decrease hyperoxaluria and prevent the recurrence of
*I noticed a similar, very much welcomed effect after a few
weeks on a regimen of 250mg of "chelated" magnesium (amino acid
chelate and magnesium oxide) and 25mg vitamin B-6 (pyridoxine
HCL) per day. I would call it more "flank pain" on my left
and right sides than "abdominal pain". I didn't even
realize that it was there until I started taking the MG and B-6
and the discomfort faded away. I know I still have several
existing stones that I'll have deal with, but if I can reduce
the occurance of more, that will be well worth the cost and
bother of the the supplements.
PubMed search on "rice bran"
of long-term rice bran treatment on stone recurrence in
Urol. 1991 Mar;67(3):237-40.
S, Morimoto S, Yasukawa S, Ohkawa T.
Urology, Wakayama Medical College, Japan.
series of 182 calcium stone formers with idiopathic
hypercalciuria underwent treatment with rice bran for 1 to 94
months. Urinary calcium excretion was considerably reduced,
but there was some increase in urinary phosphate and oxalate.
Urinary excretion of magnesium and uric acid, serum calcium,
magnesium, phosphate, uric acid, parathyroid hormone (PTH) and
ALP was unaffected. There were no obvious changes in serum
iron, zinc and copper even when patients were treated for long
periods. Rice bran was well tolerated in almost all cases and
there were no serious side effects; 49 patients have undergone
treatment for more than 3 years (average duration of
administration 5.09 years). The frequency of new stone
formation was drastically reduced (individual stone formation
rate (no./year) from 0.720 +/- 0.533 to 0.125 +/- 0.204; group
stone formation rate (no./patient-year) from 0.721 to 0.120)
compared with the 3-year period before treatment. During
treatment, 61.2% of patients remained in remission. Although
rice bran therapy should be effective in correcting absorptive
hypercalciuria, there may be limits to the overall ability of
rice bran monotherapy to prevent recurrence.
of the concentration of urinary ionic calcium and its
clinical role in urolithiasis].
Gakkai Zasshi. 1990 Dec;81(12):1896-903.
Urology, Wakayama Medical College.
concentration of urinary ionic calcium was estimated using an
ion-selective electrode and ion analyzer for healthy controls
and patients with calcium urolithiasis. The following results
were obtained: 1) After calculating the ionic strength and
calibrating the standard solutions of ionic calcium in each
urine, the urinary ionic calcium was estimated using an
ion-selective electrode and ion analyzer. The reproducibility
and accuracy of the value of urinary ionic calcium were
satisfactory. 2) There was a significant correlation between
the concentration of urinary ionic calcium and the total
calcium excretion. Although the percentage of ionic calcium
did not show any correlations among the total calcium, oxalate
and urinary pH, it had an inverse relation to urinary citrate
and phosphate. 3) In calcium stone formers, the excretion of
ionic calcium was higher than in healthy controls
significantly. 4) In hypercalciuric calcium stone formers, the
concentrations and excretions of total and ionic calcium were
significantly higher than in normocalciuric calcium stone
formers. However, the percentage of ionic calcium was not
different. 5) When the patients were treated with citrate
orally, the excretion of urinary citrate was increased, and
the excretion of ionic calcium and the percentage for total
calcium were decreased significantly. There were significant
reductions of ionic calcium in the urine after oral
administration of rice-bran. 6) The estimation of urinary
ionic calcium might be important to evaluate the urinary risk
in recurrent calcium stone, and to estimate the effects of the
preventive treatments for its recurrence.
bran in the treatment of idiopathic hypercalciuria in
patients with urinary calculosis].
Paul Med. 1989 Jan-Feb;107(1):19-24.
IL, Andriolo A, Lucon AM, Wroclawski ER, Chade J, Borelli A,
Leite MO, Sabbaga E, Arap S.
patients with recurrent nephrolithiasis and hypercalciuria
were given rice bran during 60 days. Hypercalciuria was
reduced in all patients in an average of 40%. Urinary
magnesium was reduced in 28% and oxalate excretion was
increased in 28%. The rate of decrease of urinary calcium was
65% in the absorptive type and 33% in the renal type of
for calcium stone formers with idiopathic hypercalciuria.
Urol. 1986 Dec;58(6):592-5.
S, Morimoto S, Yoshida T, Fukatani T, Yasukawa S, Ohkawa T.
efficacy of rice-bran therapy was studied in patients with
hypercalciuria who were suffering from calcium stones. The
frequency of stone episodes was reduced dramatically,
especially in "active recurrent stone formers". Urinary
calcium excretion was considerably reduced, while urinary
phosphate and oxalate were slightly increased. Urinary
magnesium, uric acid, serum calcium, phosphate, magnesium and
uric acid were not affected. There were no changes in serum
iron, copper and zinc even when patients were treated for long
periods. The treatment was tolerated well and there were no
serious side effects. Rice-bran therapy is particularly useful
in patients with hyperabsorptive hypercalciuria and it is
effective in the prevention of recurrent urinary stone
Found this while poking around on the Web:
Remedy I use is small amount of mag chloride in water on
empty stomach to run Mg ions thru the kidney which should take
out a little bit off the surface of any kidney "stone"
present. Done slowly over time, one would never notice
haven't researched this. I'll leave that as a homework
assignment for you.
Found here: http://curezone.org/forums/am.asp?i=2145367
Research using boric acid solution (1
tsp dissolved in 1 cup of boiling water, refrigerate, only keep
for a week)
High Blood Pressure
Research using 500mg of curcumin 2
times per day to "normalize" high blood pressure.
Definitely work with your physician on this one, and do not
discontinue using blood pressure meds until you know it is
working. Also, if you are on high blood pressure meds,
this may cause your blood pressure to drop to below normal,
causing dizziness, fainting, etc.
Helicobacter Pylori (stomach ulcer bacteria)
Research adding broccoli sprouts to
your diet or broccoli sprout supplements to inhibit the H.pylori
Type II Diabetes
Research using cinnamon, chromium,
ketogenic diet (look for "Diabetes" on this
Herpes Simplex virus
Low Carbohydrate Diet May
Reverse Kidney Failure in People With Diabetes
ScienceDaily (Apr. 21, 2011) — Researchers from Mount Sinai
School of Medicine have for the first time determined that the
ketogenic diet, a specialized high-fat, low carbohydrate diet,
may reverse impaired kidney function in people with Type 1 and
Type 2 diabetes. They also identified a previously unreported
panel of genes associated with diabetes-related kidney failure,
whose expression was reversed by the diet...
Michal M. Poplawski, Jason W. Mastaitis, Fumiko Isoda, Fabrizio
Grosjean, Feng Zheng, Charles V. Mobbs. Reversal of Diabetic Nephropathy
by a Ketogenic Diet. PLoS ONE, 2011; 6 (4): e18604 DOI:
Research adding 1 or 2 Tbs per day of coconut oil to your
diet. The lauric acid in the coconut oil may dissolve the
casing of the virus and reduce the frequency and severity of
cold sore outbreaks. It may also be beneficial to suffers
Preliminary research suggests that
green tea could help shield your eyes from the harmful effects
Brain Failure Notes References
pg. 1 References pg.
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January 1, 2011
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