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Wikipedia entry:
Dr. Ray Shahelien entry: 

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Observations:


See also Pyruvate
         Creatine
         Niacinamide
         Anti-oxidant trio therapy
         Mitochondrial Dysfunction

Phase I trial: Active (NCT00605930 on clinicaltrials.gov) (as of September 11, 2010).

"A bar of 2 gm of pyruvate and 1 gm of creatine, and a pill of 1 gm of niacinamide once a day for 24 weeks."
http://clinicaltrials.gov/ct2/show/NCT00605930?term=NCT00605930&rank=1

[From PubMed ID#: 20472654]

See:

Rational therapeutic approaches to progressive supranuclear palsy
Brain 2010: 133; 1578–1590
http://brain.oxfordjournals.org/content/133/6/1578.full.pdf+html

Table 1 of the above article lists "puruvate".  This must be a typo.  In the text, it refers to "pyruvate".
"Pyruvate is a free radical scavenger..."
Fernandez-Gomez FJ, Pastor MD, Garcia-Martinez EM, Melero-
Fernandez de Mera R, Gou-Fabregas M, Gomez-Lazaro M, et al.
Pyruvate protects cerebellar granular cells from 6-hydroxydopamineinduced cytotoxicity by activating the Akt signaling pathway and increasing glutathione peroxidase expression. Neurobiol Dis 2006;
24: 296–307.

Wang X, Perez E, Liu R, Yan LJ, Mallet RT, Yang SH. Pyruvate protects
mitochondria from oxidative stress in human neuroblastoma SK-N-SH
cells. Brain Res 2007; 1132: 1–9.

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Known sources:


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Natural sources:


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References:




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Updated: July 2, 2012
Inception: July 2, 2012