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- Anti-oxidant trio therapy -


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Anti-oxidant trio therapy

See also Alpha lipoic acid (ALA)
         Alpha tocopherol (vitamin E)
         N-acetylcysteine (NAC)

Single drug to arrest Alzheimer's
Arnab Ganguly, Times of India, Feb 5, 2009, 01.08am IST

A team of researchers at SSKM Hospital's bio-chemistry department is working on a medicine that will be, at one and the same time, a preventive cure for Alzheimer's and age-related diseases.

The medicine will be derived from three known anti-oxidants alpha lipoic acid, alpha tocopherol and n-acetylcysteine which are used for treating chronic obstructive pulmonary diseases, diabetes and a number of other diseases...
http://timesofindia.indiatimes.com/city/kolkata-/Single-drug-to-arrest-Alzheimers-age-woes/articleshow/4078149.cms

http://findarticles.com/p/articles/mi_8012/is_20090205/ai_n39536073/?tag=content;col1

Unfortunately, at this time (April 29, 2101), I don't know how much of each supplement to use.  For the time being, I will use the manufacturer's recommended dosage found on the bottles.

This might be the paper referred to in the Times of India article cited in my earlier post:

Neurosci Lett. 2010 Oct 11;483(2):123-6. Epub 2010 Aug 5.
Sinha M, Saha A, Basu S, Pal K, Chakrabarti S.

Department of Biochemistry, Institute of Postgraduate Medical Education and Research (IPGMER), Kolkata, West Bengal, India.
Abstract

The study has shown that in aged (22-24 months) rat brains an elevation of homocysteine level (42%) and a decrease in dehydroepiandrosterone sulphate (DHEA-S) content (32%) occur compared to those in the brains of young rats (4-6 months). Such changes in the brain levels of homocysteine and DHEA-S in aged rats are prevented, when the diet daily of the rats is supplemented with a combination of antioxidants (N-acetyl cysteine 50 mg, alpha-lipoic acid 3 mg and alpha-tocopherol 1.5 mg - each per 100 g of body weight) starting from 18 months until these are sacrificed between 22 and 24 months. The brain content of reduced glutathione is also decreased in aged rats as compared to that in young ones and the phenomenon can again be prevented completely by the same regimen of antioxidant supplementation. The changes in the levels of homocysteine and DHEA-S in aged rat brain have been related to associated glutathione depletion and oxidative stress and the implications of the results highlighted in the pathogenesis of Alzheimer's disease.

PMID: 20691758 [PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/20691758

Let's see how these quantities would translate to a person weighing 100lbs.  There are 2.2lbs per kilogram (kg).  There are 1000g per kg.  For a 100lb woman, 45.5kg
N-acetyl cysteine (NAC)    50 mg/100g (of body weight) 500mg/kg        22727mg    23.0g (WOW!)    
alpha-lipoic acid (ALA)    3 mg/100g                    30mg/kg        1363mg      1.4g
alpha-tocopherol (Vit. E)  1.5 mg/100g                  15mg/kg        682mg       0.7g

Methinks something is rotten in the state of West Bengal.

[Does this target mitochondrial dysfunction?????]


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Updated: July 2, 2012
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