"Give with a free hand, but give only your own."
-- J.R.R. Tolkien The Children of Hurin
I have nothing to sell you but hope, and
that I give you for free.
Dedicated to the memory of my mother
Patricia, who I couldn't save because I didn't know.
What I do know, I give to you.
Please save someone.
The
Distillery
(In other words, "I found
it interesting, but haven't had the time to catagorize
it yet.)
The
PC Reading List
Unlike Jean Carper who listed 100
Simple Things You Can Do to Prevent Alzheimer's and
Age-Related Memory Loss, I don't know how many things I
have listed in my Web pages. Probably dozens. But,
my list is free!
Think outside the box!
Some
things to ask the doctor about...
(Study these things.
Follow the links below for backup information. Go to
the original research papers or news articles. Print out the
information you are interested in, read it, and take it with
you the next time you see your physician.)
I. Potentially treatable conditions
that may mimic the symptoms of dementia, Parkinson's
disease, Alzheimer's
disease, corticobasal degeneration (CBD),
etc.
1) NPH (Normal Pressure Hydrocephalus)
2) Lyme Disease
3) Helicobacter pylori
infection
4) Celiac disease
(gluten metabolism) [EDIT NOTE: NEED LINKS TO MORE
DISCUSSION OF THESE]
5) Sleep apnea
6) Cold sore virus
(HSV-1, Herpes Simplex
Virus-1), see Lauric Acid,
Acyclovir
7) Vitamin B12 deficiency
8) CCSVI - Chronic CerebroSpinal
Venous Insufficiency
9) Carotid
artery
disease (Carotid stenosis)
10) Neurospirochetosis
- Invasion of the brain by spirochete bacteria such as
Periodontal
pathogen Treponemas (T. pectinovorum, T. amylovorum, T.
lecithinolyticum, T. maltophilum,
T.
medium, T. socranskii) and Borrelia burgdorferi (Lyme disease)
II. Substances found in nature that have
shown promise in relieving the
symptoms or even
the causes of neurodegenerative diseases
1) Ginkgo-biloba
2) Scyllitol - Dissolves amyloid
beta (AB) plaques and restores
mental abilities in transgenic mice (standard "animal model"
for AD research). Most abundant plant source is the
coconut palm.
3) Curcumin - (a.k.a. turmeric extract) Similar effect as scyllitol in "standard
animal model",
plus other
positive effects.
4) Phosphatidylserine
(PS)
5) Huperzine A
6) Vinpocetine
7) Cinnamon - Inihibits tau
protein hyperphosphorylation & untangles
tau
fibers that have already formed.
8) Niacinamide - Inibits tau
protein corruption, reduces quantity of
tau
protein aggregations.
9) MCT - "Medium-chain
Triglycerides" provides an alternate energy source for
neurons which have trouble metabolising
glucose. Coconut oil is rich
in several MCTs.
10) Adaptation of The
Sinatra Solution to neurodegenerative diseases with
glucose hypometabolism:
Coenzyme Q10 (CoQ10),
L-carnitine (or maybe
acetyl-L carnitine), D-ribose and magnesium to improve production
of ATP by
neuronal mitochondria
[EDIT NOTE:
NEED LINKS TO DISCUSSIONS ABOUT THESE]
11) Alpha-lipoic Acid - Antioxidant,
supports mitochondrial function, may halt
the progression of AD.
12) Grape Seed Extract - Inihibits tau protein
hyperphosphorylation & untangles
tau
fibers that have already formed. [?]
13) Aphanizomenon flos-aquae (AFA)
- May halt progression of AD and related
neurodegenerative
diseases for as long as
three years, 6
month improvement period.
14) Colostrinin - Shows
promise in slowing progression of AD.
16) Rosemary - May have compounds that prevent the breakdown of acetylcholine.
17) Green Tea (EGCG, epigallocatechin gallate) - Inhibits alpha-synuclein and
amyloid-beta fibrillogenesis, higher consumption of green tea was associated
with a lower prevalence of cognitive impairment.
18) Anatabine - Reduces "brain inflammation". A component of tobacco.
19) Trehalose - Promotes autophagy
20) Fisetin - Neuroprotective Blood Brain Barrier Penetrating Flavonoid
21) Coffee - 3 or 4 cups per day appears to prevent or at least delay progression of
MCI (Mild Cognative Impairment) to AD.
III. Dietary changes to improve artery disease and reduce the
chance of strokes
See McDougall and Mirkin
1) Improve
circulation, reverse artery disease
2) In combination with statin
drugs
3) Increase scyllitol intake from grains
and legumes
IV. Drugs currently
on the market that have been shown to slow the progression
of
neurological disease
1) Memantine (a.k.a.
Namenda: AD)
2) Enbrel (Etanercept: AD)
3) Lithium (ALS, tauopathies?)
4) Methylene blue (tauopathies)
5) Simvastatin
(Zocor: Parkinson's)
6) Desferrioxamine
(intramuscular)-- chelates iron, aluminum. Halts
AD progression.
7) Deferasirox
(oral)-- chelates iron, probably others. Possible
alternative to
desferrioxoxamine.
8) Clioquinol -
pre-occupies AB metal ion binding sites, halts AD
progression.
9) Lisinopril
- (For MS)
10) Actos - mitochondrial
dysfunction of Parkinson's
Disease
11) Metformin - tauopathies
12) Gleevec - In mouse studies,
"the drug dramatically reduced beta amyloid not
only in the blood,
but also in the brain where the drug cannot penetrate."
13) Zileuton - an FDA approved
drug used to treat asthma can reduce the formation
of
amyloid beta.
14) Tetracycline
- Disassemble amyloid beta, suppress or eliminate spirochete
of
the brain.
15) Doxycycline
- suppress or eliminate spirochete of the brain.
16) Bexarotene
(AD/amyloid beta: A drug used to treat a type of skin cancer
called
cutaneous T-cell lymphoma.)
17) Epothilone D (Epo-D)
V. Mechanical
devices that show promise in arresting the
progression of
dementia
1) COGNIShunt [proven
ineffective?]
2) Infrared
3) RF
4) Angioplasty (see more at CCSVI)
VI. Metals involved with
neuro-degenerative diseases
1) Aluminum
and Aluminosilicates
2) Copper [EDIT NOTE: ARTICLE IN NOVEMBER
2009 SCIENCEDAILY.COM THAT COPPER IS IMPORTANT IN IMMUNE
RESPONSE???]
3) Iron metabolism in Parkinsonian
Syndromes
VII. Chelation agents that can be taken orally
- to open up arteries
- remove metal ions that may cause
nerve cell damage
- remove metal ions that may
cause normally harmless (even
crucial)
proteins present in
the brain to become toxic by a catalytic
action (amyloid beta
plaques)
- remove metals from the
body. It is not known for sure if this
causes or exacerbates AD,
but the cost is very low, and the risk
of adversely affecting
your health is low. At the worst, they
will be ineffective.
1) Phytic Acid (myo-inositol
hexakisphosphate, IP6, InsP6) Naturally
occurring
"anti-nutrient" that binds to free metal ions, allowing
the body to
flush them out.
2)
Oral EDTA. EDTA is a
common food additive used to preserve the
flavor and color of
processed foods. Perhaps it can be found in
bulk, since food
processing companies must use it in this way
themselves!
3) Cilantro:
An
herb found to mobilize aluminum, mercury and some
other metals that are
then chelated by a chelating agent such as
phytic
acid or EDTA. Cheap and easily available.
4) Curcumin: Curcumin,
amoung its other salubrious
qaulities, is a
powerful iron and copper chelator.
IIV. Do blood
thinners and anti-platelet medications reduce the risk of
strokes and therefore the
worsening of vascular dementia?
1) Aspirin (reports of
developing aspirin resistance?)
2) Cumadin, etc (brand name
or generic pharmaceuticals)
IX. Are there
any natural blood thinners and anti-platelets?
-to prevent ischemic strokes (can
exacerbate hemorrhagic strokes)
-Natural blood
thinners
a. Garlic
b. Ginkgo-biloba
X. Have statin
drugs used to reduce cholesterol levels been found to
slow the progression
of Alheimer's disease or reduce the the risk
strokes by reversing
arterial sclerosis?
- Statins -
lowers cholesterol, delays AD progression.
XI. Are there
any alternative therapies available?
- IV EDTA chelation
therapy-- chelates most metals. Reported by
chelation
therapists to halt and reverse AD symptoms.
- Infrared (1072nm)
Nutritional
alternatives: Things you can try while coaxing the
physicians to get off their butts and try something.
[EDIT NOTE: THE NUTRITIONAL ALTERNATIVES PAGES IS OUT OF
DATE AND NEEDS MUCH UPDATING]
"First
Aid"
for AD Sundowning:
1 cup apple juice (or non-alcoholic apple cider) 2 times per
day
20g of MCT oil from coconut meat, coconut oil, or refined "MCT
oil".
- 2 "Mounds" candy bars, or
- 2x2" square of fresh coconut meat, or
- 3 coconut macaroons, or
- "coconut milk" as sold for Thai cooking
(quantity TBD), or
- 7 tsp. of "MCT oil", as sold for
bodybuilding
Curcumin
- 500mg capsules 2x per day, or
- 1 Tbsp unrefined ground turmeric spice 2x
per day, or
- Curry dishes, at least 3x per week
See
also Prazosin
The purpose of this web site is to help my mother and is an educational service to others. I needed a way to keep track of the mountains of information I was digging up on the various neurological diseases she has been diagnosed with by the various physicians she has seen. So, I started to put it on this web page for my own use, and that of my family. It is literally my electronic notebook, which I am constantly updating, revising, correcting, and expanding. Perhaps you can also gather some information from all this for when you meet with a physician to discuss what can be done for someone suffering from brain failure: Alzheimer's disease (AD), Vascular Dementia (VD), Normal Pressure Hydrocephalus (NPH), or any of the Parkinsonian Syndromes such as corticobasal degeneration (CBD) or progressive supranuclear palsy (PSP). You will have a list of questions to ask, and sources to read so that you will know what to ask.
The real challenge may be...Even if you find something in these pages you think might work, and the doctors agree with it, the real challenge might be getting the patient to change their lifestyle. Habbits and behavior will probably be your greatest obstacle. This is like watching your grandfather smoke himself to death with cigarettes. You know they are bad for him, and that he is smoking way way too much. But what can you do? There really just isn't a way to stop someone hell-bent on self destruction, so you must just stand there helpless watching him pound nails in his own coffin. A person who is starting to show the signs of Brain Failure (dementia, Alzheimer's Disease, Vascular Dementia, NPH, etc.), may not even be physically or mentally able to help themselves. They may not have an appetite to eat better food. They may not be able to swallow pills or feed themselves. Their primary caregiver may not believe that mere lifestyle and eating habbits and herbs and medicine or anything can help. Fatalism or a state of denial on the part of the caregiver can doom the dementia sufferer to an inevitable decline. The only way pills can help you, if they can, is if you have enough faith to swallow them.
This may be your greatest
challenge. This, more than anything else, you may not be
able to overcome.
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
June 13, 2012
As I walk through the nursing home to visit my father, I
pass by so many elderly people, most of whom are there
because their minds are failing and they just can't take
care of themselves any more. I know things, things I
have presented to you here. It breaks my heart to see
people that I believe I could help just by telling someone
of the things I know. But I can't. They would
think me crazy.
Home Preface Brain Failure Notes Notes II References pg. 1 References pg. 2
Nutritional Alternatives Patricia's Protocol Tauopathy Discussion Forum
Correspondence Newsletters Memory Enhancement PC Home Curcumin The Distillery
Click to join tauopathies
********************************************************************************************You can reach me by mai|ing to
"perpetualcommotion.com", at gmail dot com.
Updated November 27,
2010
Inception June 5, 2006
A
"Death Club" refers to an
on-line community, such as a message board or discussion group
that is obsessed with death at the ultimate solution-- the final solution-- to all
the problems of life. It is a collection of people who,
at best, seek to find justification for inaction that will
expedite the demise of someone who has become an emotional or
physical drain on them. At worst, they want to actively
hurry things along. The "Club" provides support for
actions that would cause a burdened conscience. This is
a form of "collective salvation". Unfortunately, people
must face judgment as individuals, not as a member of a
group. And even if a group approves, this does not
remove guilt, as former members of the German National
Socialist party (Nazi) came to realize. With regard to
Internet discussion groups, "death club" means that the topics
of discussion are dominated by people who regard death of
other people as the ultimate solution to all their problems,
and push an agenda of depression and hopelessness.
Alz.org's
"Medications and Treatments" forum
In December of 2011, the Alzheimer's Association remove the
"Medications and Treaments for Alzheimer's Disease" discussion
forum. This is truly sad development since that was one
of the most informative discussion groups for AD I have
found. I have not found an alternative, other than to
steer people to the Yahoo Group "Tauopathies"
(See the link above). There is (for the time being) a
link to an archive
of the posts to that board available.