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- Walnuts -
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References:
Simple snack may offer Alzheimer's protection
By Matt Cantor
Published October 27, 2014
FoxNews.com
1 to 1.5 oz of walnuts per day...
Those given the walnuts performed far better in mazes and other tests...
http://www.foxnews.com/health/2014/10/27/simple-snack-may-offer-alzheimer-protection/
Walnuts appear to delay onset of Alzheimer’s disease, new study finds
By Fredrick Kunkle October 21
Washington Post
http://www.washingtonpost.com/national/health-science/walnuts-appear-to-delay-onset-of-alzheimers-disease-new-study-finds/2014/10/20/d357bc7e-58a6-11e4-b812-38518ae74c67_story.html
New research on walnuts and the fight against Alzheimer's disease
Animal study reveals potential brain-health benefits of a walnut-enriched diet
Folsom, Calif., (October 21, 2014)
...The research group examined the effects of dietary supplementation on mice with 6 percent or 9 percent walnuts, which are equivalent to 1 ounce and 1.5 ounces per day, respectively, of walnuts in humans. This research stemmed from a previous cell culture study led by Dr. Chauhan that highlighted the protective effects of walnut extract against the oxidative damage caused by amyloid beta protein. This protein is the major component of amyloid plaques that form in the brains of those with Alzheimer's disease...
http://www.eurekalert.org/pub_releases/2014-10/es-nro102114.php
Resources:
1. Halvorsen BL, Carlsen MH, Phillips KM, Bohn SK, Holte K, Jacobs DR, Blomhoff R (2006) Content of redox-active compounds (ie, antioxidants) in foods consumed in the United States. Am J Clin Nutr 84, 95-135
2. 2014 Alzheimer's Disease Facts and Figures. Alzheimers Dement. 2014;2:16-17. Available from: http://www.alz.org/downloads/Facts_Figures_2014.pdf
3. Muthaiyah B, Essa MM, Chauhan V, Chauhan A (2011) Protective effects of walnut extract against amyloid beta peptide-induced cell death and oxidative stress in PC12 cells. Neurochem Res 36, 2096-2103.
4. Pan A, Chen M, Chowdhury R, HY Wu J, Sun Q, Campos H, Mozaffarian D, Hu FB (2012) Alpha linolenic acid and risk of cardiovascular disease: a systemic review and meta-analysis. Am J Clin Nutr. 96:6:1262-1273.
5. Innis SM (2007) Dietary (n-3) fatty acids and brain development. J Nutr 137, 855-859.
Fight against Alzheimer's disease: New research on walnuts
Date: October 21, 2014
Source: IOS Press BV
Summary: An new animal study reveals potential brain-health benefits of a walnut-enriched diet. Researchers suggest that a diet including walnuts may have a beneficial effect in reducing the risk, delaying the onset, slowing the progression of, or preventing Alzheimer’s disease.
http://www.sciencedaily.com/releases/2014/10/141021125744.htm
Journal Reference:
Dietary Supplementation of Walnuts Improves Memory Deficits and Learning Skills in Transgenic Mouse Model of Alzheimer's Disease.
Abha Chauhan, PhD et al.
Journal of Alzheimer's Disease, Volume 42, Number 4 / 2014 DOI: 10.3233/JAD-140675
Dietary supplementation of walnuts improves memory deficits and learning skills in transgenic mouse model of Alzheimer's disease.
J Alzheimers Dis. 2014 Jan 1;42(4):1397-405. doi: 10.3233/JAD-140675.
Muthaiyah B, Essa MM, Lee M, Chauhan V, Kaur K, Chauhan A.
Abstract: Previous in vitro studies have shown that walnut extract can inhibit amyloid-β (Aβ) fibrillization, can solubilize its fibrils, and has a protective effect against Aβ-induced oxidative stress and cellular death. In this study, we analyzed the effect of dietary supplementation with walnuts on learning skills, memory, anxiety, locomotor activity, and motor coordination in the Tg2576 transgenic (tg) mouse model of Alzheimer's disease (AD-tg). From the age of 4 months, the experimental groups of AD-tg mice were fed custom-mixed diets containing 6% walnuts (T6) or 9% walnuts (T9), i.e., equivalent to 1 or 1.5 oz, respectively, of walnuts per day in humans. The control groups, i.e., AD-tg and wild-type mice, were fed a diet without walnuts (T0, Wt). These experimental and control mice were examined at the ages of 13-14 months by Morris water maze (for spatial memory and learning ability), T maze (for position discrimination learning ability), rotarod (for psychomotor coordination), and elevated plus maze (for anxiety-related behavior). AD-tg mice on the control diet (T0) showed memory deficit, anxiety-related behavior, and severe impairment in spatial learning ability, position discrimination learning ability, and motor coordination compared to the Wt mice on the same diet. The AD-tg mice receiving the diets with 6% or 9% walnuts (T6 and T9) showed a significant improvement in memory, learning ability, anxiety, and motor development compared to the AD-tg mice on the control diet (T0). There was no statistically significant difference in behavioral performance between the T6/T9 mice on walnuts-enriched diets and the Wt group on the control diet. These findings suggest that dietary supplementation with walnuts may have a beneficial effect in reducing the risk, delaying the onset, or slowing the progression of, or preventing AD.
PMID: 25024344 [PubMed]
http://www.ncbi.nlm.nih.gov/pubmed/25024344
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