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Novel Herbal Compound Offers
Potential to Prevent and Treat Alzheimer's Disease
Feb. 15, 2013 — Administration of the active compound
tetrahydroxystilbene glucoside (TSG) derived from the Chinese
herbal medicine Polygonum multiflorum Thunb, reversed both
overexpression of α-synuclein, a small protein found in the brain,
and its accumulation using a mouse model of Alzheimer's disease...
http://www.sciencedaily.com/releases/2013/02/130217085301.htm
Tetrahydroxystilbene glucoside
antagonizes age-related α-synuclein overexpression in the
hippocampus of APP transgenic mouse model of Alzheimer's
disease.
Zhang L, Yu S, Zhang R, Xing Y, Li Y, Li L.
Restor Neurol Neurosci. 2013;31(1):41-52. doi: 10.3233/RNN-120260.
Source: Key Laboratory for Neurodegenerative Diseases of Ministry
of Education, Department of Pharmacology, Xuanwu Hospital of
Capital Medical University, Beijing, China.
Abstract
PURPOSE: To investigate the mRNA and protein alterations of
α-synuclein in the brain of Alzheimer's disease-like mouse model
at the different ages, and to evaluate the effects of
2,3,5,4'-tetrahydroxy stilbene-2-O-β-D-glucoside (TSG) on
α-synuclein expression.
METHODS: TSG (120 or 240 μmol kg(-1)d(-1)) was intragastrically
administered to APPV717I transgenic (Tg) mice at 4- or
10-month-old for 6 months.
RESULTS: mRNA expression of α-synuclein increased in hippocampus
in 4 month to 16 month old Tg mice compared with age-matched
control. α-synuclein protein expression in hippocampus also
increased in 4 month to 16 month old Tg mice significantly.
Significant down-regulation of α-synuclein mRNA and protein
expression in hippocampus was found after treatment of TSG for 6
months in both 10- and 16-month-old Tg mice. Production of dimer
and tetramer of α-synuclein protein in Tg mice was inhibited after
treatment with TSG.
CONCLUSIONS: The expression and aggregation of α-synuclein was
age-dependently increased in Tg mice. TSG not only prevents
over-expression of α-synuclein at an early stage, but also
reverses the increased expression of α-synuclein and inhibits the
aggregation at the late stage of Tg mice. TSG may have potential
to the prevention and treatment of Alzheimer's diseases.
PMID: 23160059 [PubMed] http://www.ncbi.nlm.nih.gov/pubmed/23160059
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