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TIMP2

Names: TIMP2, tissue inhibitor of metalloproteases 2

Comment:
Researchers think TIMP2 from the umbilical cord blood repairs the hippocampus, a part of the brain which in both mice and humans is critical for converting experiences into long-term memories.

Umbilical cord blood from babies could help bring back memory for dementia patients
By Sarah Knapton, Science Editor
19 April 2017 • 6:00pm
http://www.telegraph.co.uk/science/2017/04/19/umbilical-cord-blood-babies-could-help-bring-back-memory-dementia/

Protein in human umbilical cord blood rejuvenates old mice's impaired learning, memory
Date: April 19, 2017
Source: Stanford University Medical Center
Summary: Human umbilical cord blood can rejuvenate learning and memory in older mice, according to a new study. The findings could lead to new treatments for age-associated declines in mental ability.
https://www.sciencedaily.com/releases/2017/04/170419131753.htm

Journal Reference:
Human umbilical cord plasma proteins revitalize hippocampal function in aged mice.
Joseph M. Castellano, Kira I. Mosher, Rachelle J. Abbey, Alisha A. McBride, Michelle L. James, Daniela Berdnik, Jadon C. Shen, Bende Zou, Xinmin S. Xie, Martha Tingle, Izumi V. Hinkson, Martin S. Angst, Tony Wyss-Coray.
Nature, 2017; DOI: 10.1038/nature22067
http://dx.doi.org/10.1038/nature22067

NSAIDs: Painkillers, Inflammation Inhibitors, Anti-cancer Drugs And New De-methylating Agents
Date: March 28, 2008
Source: Society for Experimental Biology and Medicine
Summary: Researchers have revealed a new mechanism by which non-steroidal anti-inflammatory drugs attenuate tumor invasion and metastasis. The research provides new insights for the understanding of the anti-cancer effects of NSAIDs.
...The research team found that NSAIDs up-regulated several anti-metastatic genes including secreted protein acidic and rich in cysteine (SPARC), thrombospindin-1 (TSP-1), TSP-3 and tissue inhibitors of metalloproteinase-2 (TIMP-2) in human lung cancer cells…
https://www.sciencedaily.com/releases/2008/03/080326164437.htm

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