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- Phospholipase C -
General Information:
Names:
Wikipedia entry:
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Observations:
Spirochetes
release phospholipase C and phospholipase C is the trigger for
Alzheimer's disease. Many factors other than chronic bacterial
and viral infections can contribute to phospholipase C activity
(high blood glucose levels, angiotensin II, mercury, and
aluminium fluoride, for instance). Certain antibiotics can
potentially be used to treat Alzheimer's disease whether the
cause is a persistent infection or not, because certain
antibiotics are peroxynitrite scavengers, and peroxynitrites may
be a step in the Alzheimer's disease process.
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Known sources:
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Natural sources:
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References:
Synthesis and
secretion of phospholipase C by oral spirochetes.
Siboo R, al-Joburi W, Gornitsky M, Chan EC.
J Clin Microbiol. 1989 Mar;27(3):568-70.
Source: Department of Microbiology and Immunology, Faculty of
Medicine, McGill University, Montreal, Quebec, Canada.
Abstract
Four strains of oral treponemes and Treponema phagedenis Reiter
synthesize and secrete phospholipase C (PLC), which was detected
by the hydrolysis of p-nitrophenylphosphorylcholine. PLC was
detected in gingival crevicular fluid from diseased but not from
healthy sulci. The initiation and progression of periodontal
lesions may begin with the hydrolysis of membrane phospholipids by
PLC.
PMID: 2715327 [PubMed] PMCID: PMC267363
http://www.ncbi.nlm.nih.gov/pubmed/2715327
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC267363/
Calcium regulates processing of
the Alzheimer amyloid protein precursor in a protein kinase
C-independent manner.
Buxbaum JD, Ruefli AA, Parker CA, Cypess AM, Greengard P.
Proc Natl Acad Sci U S A. 1994 May 10;91(10):4489-93.
Source: Laboratory of Molecular and Cellular Neuroscience,
Rockefeller University, New York, NY 10021.
Abstract
Various first messengers linked to phospholipase C, including
acetylcholine and interleukin 1, regulate the production both of
the secreted form of the amyloid protein precursor (APP) and of
amyloid beta-protein. We have now identified intracellular signals
which are responsible for mediating these effects. We show that
activation of phospholipase C may affect APP processing by either
of two pathways, one involving an increase in protein kinase C and
the other an increase in cytoplasmic calcium levels. The effects
of calcium on APP processing appear to be independent of protein
kinase C activation. The observed effects of calcium on APP
processing may be of therapeutic utility.
PMID: 8183935 [PubMed] PMCID: PMC43811
http://www.ncbi.nlm.nih.gov/pubmed/8183935
Full Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC43811/
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Updated: July 25, 2012
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