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- Multi-Infarct Dementia -
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[leukoaraiosis]
Possible cause of common dementia found, opening avenues for
treatment
Date: October 30, 2014
Source: University Health Network (UHN)
Summary: A major cause of dementia has been potentially
discovered, scientists report. In the type of dementia studied,
there is damage to the white matter (nerve fibres) of the brain
apparent on computerized tomography (CT) and magnetic resonance
imaging (MRI) scans of older individuals… white matter disease
(also called leukoaraiosis) may actually be the result of many
tiny unnoticed strokes accumulating over time…
http://www.sciencedaily.com/releases/2014/10/141030100521.htm
Journal Reference:
1.John Conklin, Frank L. Silver, David J. Mikulis, Daniel M.
Mandell. Are acute infarcts the cause of leukoaraiosis? Brain
mapping for 16 consecutive weeks. Annals of Neurology, 2014;
DOI: 10.1002/ana.24285
Are acute infarcts the cause of leukoaraiosis? Brain mapping
for 16 consecutive weeks.
Ann Neurol. 2014 Oct 4. doi: 10.1002/ana.24285. [Epub ahead of
print]
Conklin J1, Silver FL, Mikulis DJ, Mandell DM.
Abstract: Neuroimaging of older adults commonly reveals
abnormality (leukoaraiosis) in the cerebral white matter.
Studies have established that extensive leukoaraiosis predicts
dementia and disability, but the pathogenesis of leukoaraiosis
remains unclear. We recruited 5 patients with leukoaraiosis and
performed magnetic resonance mapping of the brain for 16
consecutive weeks. We observed tiny lesions arising de novo in
the cerebral white matter. These lesions were clinically silent.
They had the signature features of acute ischemic stroke. With
time, the characteristics of these lesions approached those of
pre-existing leukoaraiosis. Together, these findings suggest
that tiny silent acute infarcts are a cause of leukoaraiosis.
Ann Neurol 2014.
PMID: 25283088 [PubMed]
http://www.ncbi.nlm.nih.gov/pubmed/25283088
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