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- Melatonin -
General Information:
Names:
Wikipedia entry:
Dr. Ray Shahelien entry:
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References:
Melatonin May Halt the Progression of Alzheimer’s Disease
By Darin Ingels, ND
"Healthnotes Newswire (December 20, 2001)—The hormone melatonin
may block key steps in the development of harmful protein
deposition in the brain that leads to Alzheimer’s disease,
according to a new report in Biochemistry.1 Although the cause
of Alzheimer’s disease is unknown, it appears that people with
this disease produce a precursor protein (Ab peptide) in the
brain that is transformed into amyloid, a larger protein mass
that contributes to the symptoms associated with this condition.
Previously published studies indicate that inheritance of a cell
marker called apolipoprotein E4 (Apo E4) increases the risk of
developing Alzheimer’s disease as it binds to the precursor
protein and facilitates the production of amyloid.2 This current
study indicates that melatonin, in the presence of Apo E4,
inhibits amyloid formation and thereby possibly slows or halts
the progression of Alzheimer’s disease."
http://www.healthnotes.com/online/Back_issues/newswire_2001_12_20_3.htm
Melatonin:
Prevention of
isoproterenol-induced
tau hyperphosphorylation by melatonin in the rat.
Wang XC, Zhang J, Yu X, Han L, Zhou ZT, Zhang Y, Wang JZ.
Department of Pathophysiology, Tongji Medical College, Huazhong
University of Science and Technology
Sheng Li Xue Bao. 2005 Feb 25;57(1):7-12.
"Hyperphosphorylated microtubule-associated protein tau is the
major
protein component of neurofibrillary tangles in the brain of
patients
with Alzheimer's disease (AD). Until now, there is no effective
cure to
arrest this hyperphosphorylation. The present study was designed
to
explore the in vivo preventive effect of melatonin on
Alzheimer-like
tau hyperphosphorylation. Isoproterenol, a beta-receptor
agonist, was
used to induce tau hyperphosphorylation, and for preventive
effect of
melatonin, the rats were injected intraperitoneally with
melatonin for
5 d before hippocampi infusion of isoproterenol. The level of
tau
phosphorylation was detected by Western blot and
immunohistochemistry
using sites specific antibodies (PHF-1 and Tau-1), and it was
normalized by non-phosphorylation dependent total tau antibody
(111e).
The results by Western blot showed that the immunoreaction of
tau at
PHF-1 epitope was enhanced, and the reaction at Tau-1 epitope
was
weakened significantly at 48 h after injection of isoproterenol,
suggesting hyperphosphorylation of tau at Ser 396/Ser 404
(PHF-1) and
Ser199/Ser 202 (Tau-1) sites. Similar results were observed by
immunohistochemistry staining, in which hyperphosphorylated tau
was
mainly detected in mossy fibers of hippocampal CA3 region.
Pre-injection of rats with melatonin intraperitoneally arrested
effectively the isoproterenol-induced tau hyperphosphorylation
at both
Tau-1 and PHF-1 sites, implying the preventive effect of
melatonin in
Alzheimer-like tau hyperphosphorylation."
PMID: 15719129 [PubMed]
http://www.ncbi.nlm.nih.gov/pubmed/15719129?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
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Updated: July 25, 2012
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