www.perpetualcommotion.com
"Give with a free hand, but give only your own."
 -- J.R.R. Tolkien The Children of Hurin
- Gum Health -

General Information:

Wikipedia entry:

********************************************************************************************
 Observations:

Tooth/Gum Health

Men with inadequate natural masticatory function who did not wear dentures had a 91% greater risk of dementia than those with adequate natural masticatory function. 1,2,3

Tooth Loss May Be Linked to Memory Loss
 Gum infection may cause inflammation that affects the brain, researcher suggests
 TUESDAY, Jan. 4 (HealthDay News)
 http://www.businessweek.com/lifestyle/content/healthday/648432.html

The Periodontal Solution – Healthy Gums Naturally

http://www.theintegrativedentist.com/oralirrigation.html

http://www.theintegrativedentist.com/references.html


Tooth Decay
"Most people over 60 have root cavities as a result of gum disease ... Although hydrogen peroxide is bacteriocidal and sodium bicarbonate is bacteriostatic, there ..."
 http://www.dentalgentlecare.com/tooth_decay.htm


See BANA Bacterial Home Test. http://mizar5.com/bana1.html

Dr. Paul H. Keyes

Dr. Keyes is the founder of the International Dental Health Foundation
Education: D.D.S., University of Pennsylvania School of Dental Medicine (1941); B.A., University of Rochester (1944); M.S. in Anatomy, University of Rochester (1945); Fellowship in Orthodontics, Harvard University School of Dental Medicine (1948).
[Some interesting ideas, but need references for some claims…]
http://mizar5.com/keyes.html


In many cases, sodium bicarbonate was found to be effective against periodontal microorganisms. In a study by Rams et al., a five-minute exposure to sodium bicarbonate quickly immobilized spirochetes and motile rods. (9)
(9.) Rams TE, Keyes PH, Wright WE, Howard SA. Long-term effects of microbiologically modulated periodontal therapy on advanced adult periodontitis. J Am Dent Assoc. 1985;111(3): 429-41.

Long-term effects of microbiologically modulated periodontal therapy on advanced adult periodontitis.
Rams TE, Keyes PH, Wright WE, Howard SA.
J Am Dent Assoc. 1985 Sep;111(3):429-41.
PMID:2995468[PubMed]
[ NEED LINK ]


The use of phase-contrast microscopy and chemotherapy and the diagnosis and treatment of periodontal lesions-an initial report.
Keyes PH, Wright WE, Howard SA.
Quintessence Int. 1978;9(1): 51-56.

http://www.smartahealth.com/gum_disease.html


The use of sodium bicarbonate in oral hygiene products and practice.
E Newbrun
Department of Stomatology, University of California, San Francisco, San Francisco, California, USA.
Early dentifrices contained natural ingredients, mostly in coarse particle form, and were quite abrasive. Salts, either sodium chloride, sodium bicarbonate, or a mixture of both, have also been used for tooth cleaning because of their ready availability and low cost. Because of both their relatively low intrinsic hardness and their high solubility, another advantage is low abrasivity. Their biggest disadvantage is a salty, unpalatable taste. Many modern dentifrices that contain sodium bicarbonate, either as the sole abrasive or one of several, disguise the saltiness with flavoring and sweetening agents. An almost inverse relationship exists between the percentage of baking soda in a dentifrice and its abrasivity. Sodium bicarbonate has no anticaries activity per se but is compatible with fluoride. In high concentrations, sodium bicarbonate is bactericidal against most periodontal pathogens. Most clinical studies have not found significant differences in periodontal response to baking soda as compared with other commercial dentifrices, probably because of its rapid clearance from the gingival sulcus. Sodium bicarbonate may not be the "magic bullet" for curing dental diseases, but its safety (if ingested), low abrasivity, low cost, and compatibility with fluoride make it a consummate dentifrice ingredient. Community Dent Oral Epidemiol. 1980 ;8 (5):230-6 7006899 Cit:2
http://lib.bioinfo.pl/meid:84192
Antimicrobial Properties of Hydrogen Peroxide and Sodium Bicarbonate Individually and in Combination Against Selected Oral, Gram-negative,Fa
cultative Bacteria
K. T. MIYASAKI, R. J. GENCO, and M. E. WILSON
http://jdr.sagepub.com/content/65/9/1142.full.pdf


Keyes Technique: The Fallacy of the Usage of Hydrogen Peroxide in Periodontal Therapy
http://www.drbui.com/arthydrogenperoxide.html

Poor dental health has been linked to an increased risk for dementia, new research shows.
Source: Medscape
In a study of more than 4000 elderly adults in Japan, those who had few teeth and who did not use dentures or who did not visit a dentist regularly had a significantly higher risk for dementia onset than the participants who practiced better dental health practices...
http://r20.rs6.net/tn.jsp?e=001NJkHqF6BqziZqEtbJhoHGVUsG1vnQuEzFeCQiPaoA32MSt-J_NlLnAvqEFKoZ6a8x-rVR4m4ExcKivyITNg67fxSZCwvjPuetl_qm1oSoZv6VHBJHEVcqWr3lmaatDK5TeHzLUCHx2I=

Gum inflammation:

http://www.alzconnected.org/archive.aspx?g=posts&t=17902


Periodontal (gum) disease

http://alzheimers.infopop.cc/eve/forums/a/tpc/f/762104261/m/4211047603?r=9701028603#9701028603

Gum Inflammation Linked to Alzheimer's Disease

ScienceDaily (Aug. 4, 2010) — NYU dental researchers have found the first long-term evidence that periodontal (gum) disease may increase the risk of cognitive dysfunction associated with Alzheimer's disease in healthy individuals as well as in those who already are cognitively impaired... "The research suggests that cognitively normal subjects with periodontal inflammation are at an increased risk of lower cognitive function compared to cognitively normal subjects with little or no periodontal inflammation"...
 http://www.sciencedaily.com/releases/2010/08/100803112811.htm

New York University (2010, August 4). Gum inflammation linked to Alzheimer's disease. ScienceDaily. Retrieved August 7, 2011
But what is the connection? Could it be the same as the possible connection between an H.pylori infection of the stomach and AD: excess TNF-alpha production?


While looking up an article about resveratrol, I stumbled across this one. What I found interesting is that these substances may decrease the influence of TNF-alpha (which is what drugs like Enbrel block).

Study on Effects of Resveratrol and Quercetin on Inflammation and Insulin Resistance
ScienceDaily (Dec. 23, 2010) — A study was carried out to examine the extent to which quercetin and trans-resveratrol (RSV) prevented inflammation or insulin resistance in primary cultures of human adipocytes treated with tumor necrosis factor-a (TNF-a) -- an inflammatory cytokine elevated in the plasma and adipose tissue of obese, diabetic individuals. Cultures of human adipocytes were pretreated with quercetin and trans-RSV followed by treatment with TNF-a. Subsequently, gene and protein markers of inflammation and insulin resistance were measured. The authors report that quercetin, and to a lesser extent trans-RSV, attenuated the TNF-a-induced expression of inflammatory genes...
http://www.sciencedaily.com/releases/2010/12/101223104042.htm


Inflammatory cytokines, adiponectin, insulin resistance and metabolic control after periodontal intervention in patients with type 2 diabetes and chronic periodontitis.
Sun WL, Chen LL, Zhang SZ, Wu YM, Ren YZ, Qin GM.
Source
Department of Oral Medicine and Periodontology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, China.
Intern Med. 2011;50(15):1569-74. Epub 2011 Aug 1.

Abstract
Objective To evaluate the effects of periodontal intervention on inflammatory cytokines, adiponectin, insulin resistance (IR), and metabolic control and to investigate the relationship between type 2 diabetes mellitus (T2DM) and moderately poor glycemic control and chronic periodontitis. Methods and Patients A total of 190 moderately poorly controlled (HbA1c between 7.5% and 9.5%) T2DM patients with periodontitis were randomly divided into two groups according to whether they underwent periodontal intervention: T2DM-NT and T2DM-T group. The levels of serum adiponectin, C-reactive protein (CRP), tumor necrosis factor α (TNF-α), interleukin-6 (IL-6), lipid profile, glucose, insulin, homeostasis model of assessment - insulin resistance (HOMA-IR) and homeostasis model assessment of β-cell function (HOMA-β) were measured at baseline and after 3 months. Results The levels of clinical periodontal variables, the probing depth, attachment loss, bleeding index, and plaque index were improved significantly in T2DM-T group after 3 months compared to T2DM-NT group (all p<0.01). After 3 months, the serum levels of hsCRP, TNF-α, IL-6, fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c), fasting insulin (FINS) and HOMA-IR index decreased, and adiponectin was significantly increased in T2DM-T group compared to those in the T2DM-NT group (p<0.05 or p<0.01). Conclusion Periodontal intervention can improve glycemic control, lipid profile and IR, reduce serum inflammatory cytokine levels and increase serum adiponectin levels in moderately poorly controlled T2DM patients. PMID: 21804283
http://www.ncbi.nlm.nih.gov/pubmed/21804283

Neurology
 Issue: Volume 74(14), 6 April 2010, pp 1157-1158
 "We agree with Dr. Kamer that periodontitis probably plays an important role in disease progression in AD. Periodontitis is a good example of a peripheral chronic infectious disease known to be associated with the production of systemic proinflammatory cytokines. including TNF-[alpha], interleukin-6, and interleukin-1[beta].5"
SYSTEMIC INFLAMMATION AND DISEASE PROGRESSION IN ALZHEIMER DISEASE
 Kamer, Angela R.
 Author Information
 New York, NY
To the Editor:
We read the article by Holmes et al.1 with interest. Holmes et al.2 continue their pioneering work and now address a significant and highly controversial question: Does peripheral inflammation contribute to the progression of Alzheimer disease (AD)?...
 [ NEED link ]

********************************************************************************************
 Known sources:

********************************************************************************************
 Natural sources:

********************************************************************************************
 References:

1. Dental health linked to dementia risk: study
Mon Aug 20, 2012 8:33pm EDT
Aug 21 (Reuters) - People who keep their teeth and gums healthy with regular brushing may have a lower risk of developing dementia later in life, according to a U.S. study.
http://www.reuters.com/article/2012/08/21/health-dementia-teeth-idUSL4E8JL00020120821

2. Dentition, dental health habits, and dementia: the leisure world cohort study.
 Paganini-Hill A, White SC, Atchison KA.
 J Am Geriatr Soc. 2012 Aug;60(8):1556-63. doi: 10.1111/j.1532-5415.2012.04064.x. Epub 2012 Aug 2.
 Source: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California; Department of Neurology, University of California at Irvine, Irvine, California.
 Abstract...
 RESULTS: Men with inadequate natural masticatory function who did not wear dentures had a 91% greater risk of dementia than those with adequate natural masticatory function (≥10 upper teeth and ≥6 lower teeth). This risk was also greater in women but not significantly so. Dentate individuals who reported not brushing their teeth daily had a 22% to 65% greater risk of dementia than those who brushed three times daily.
 CONCLUSION: In addition to helping maintain natural, healthy, functional teeth, oral health behaviors are associated with lower risk of dementia in older adults
 PMID: 22860988 [PubMed]
 http://www.ncbi.nlm.nih.gov/pubmed/22860988

3. Dentition, Dental Health Habits, and Dementia: The Leisure World Cohort Study
 Annlia Paganini-Hill PhD, Stuart C. White DDS, PhD, Kathryn A. Atchison DDS, MPH
 The American Geriatrics Society, Article first published online: 2 AUG 2012
 DOI: 10.1111/j.1532-5415.2012.04064.x
 http://onlinelibrary.wiley.com/doi/10.1111/j.1532-5415.2012.04064.x/abstract


********************************************************************************************
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
 Home   Preface   Brain Failure Notes   Notes II References pg. 1   References pg. 2
Nutritional Alternatives   Patricia's Protocol   Tauopathy Discussion Forum
Correspondence  Newsletters   Poems   Memory Enhancement  

Click to join tauopathies
********************************************************************************************
 Questions or comments,contact "perpetualcommotion.com" at gmail.com
 Updated: July 2, 2012
 Inception: July 2, 2012