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- Granulocyte-colony Stimulating Factor(GCSF) -


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Wikipedia entry:
Dr. Ray Shahelien entry: 

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 Granulocyte-colony Stimulating Factor(GCSF)

This drug is apparently available and in use for other diseases. Good luck
convincing a physician to use this "off label".

Alzheimer's Symptoms Reversed: Blood Stem Cell Growth Factor Reverses Memory Decline In Mice
ScienceDaily (July 2, 2009)

The granulocyte-colony stimulating factor (GCSF) significantly reduced levels of the brain-clogging protein beta amyloid deposited in excess in the brains of the Alzheimer's mice, increased the production of new neurons and promoted nerve cell connections.

The researchers showed that injections under the skin of filgrastim (Neupogen®) -- one of three commercially available GCSF compounds -- mobilized blood stem cells in the bone marrow and neural stem cells within the brain and both of these actions led to improved memory and learning behavior in the Alzheimer's mice. "The beauty in this less invasive approach is that it obviates the need for neurosurgery to transplant stem cells into the brain,

GCSF is a blood stem cell growth factor or hormone routinely administered to cancer patients whose blood stem cells and white blood cells have been depleted following chemotherapy or radiation. GCSF stimulates the bone marrow to produce more white blood cells needed to fight infection. It is also used to boost the numbers of stem cells circulating in the blood of donors before the cells are harvested for bone marrow transplants...

GCSF has been used and studied clinically for a long time, but we're the first group to apply it to Alzheimer's disease...
http://www.sciencedaily.com/releases/2009/07/090701160557.htm

 


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Updated: July 2, 2012
Inception: July 2, 2012