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- Fisetin -
General
Information:
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Observations:
Fisetin
From
Wikipedia:
http://en.wikipedia.org/wiki/Fisetin
Search
for fisetin from online supplement suppliers, such as Amazon.com
or Swanson.com
Flavonoids could represent two-fisted
assault on diabetic complications and nervous system disorders
Salk Scientists Say: It's not an Apple a
day after all - it's Strawberries!
June 27,
2011
http://www.salk.edu/news/pressrelease_details.php?press_id=500
Fisetin
supplement, flavonoid extract, memory help? by Ray Sahelian,
M.D.
http://www.raysahelian.com/fisetin.html
A natural chemical found in strawberries
boosts memory in healthy mice
Maher:
"That suggested to us that these compounds might be particularly
beneficial, since they might not only protect neural cells from
dying but might be able to promote new connections between nerve
cells."
http://www.chemlin.net/news/2006/oct2006/fisetin.htm
Fisetin Shows Promise Against Huntington's Disease
http://alzheimersweekly.com/content/fisetin-shows-promise-against-huntingtons-disease
Strawberries Outperform An Apple A Day
http://alzheimersweekly.com/content/strawberries-outperform-apple-day
37
strawberries a day keep doctors away
http://articles.timesofindia.indiatimes.com/2011-07-14/diet/29769521_1_diabetes-mice-strawberries
From
Sept. 2008… dosage discussion…
http://www.longecity.org/forum/topic/23912-fisetin/
PubMed
search on "Fisetin"
http://www.ncbi.nlm.nih.gov/pubmed?term=fisetin
A Series of Novel Neuroprotective Blood
Brain Barrier Penetrating Flavonoid Drugs to Treat Acute
Ischemic Stroke.
Lapchak
PA.
Source:
Director of Translational Research, Cedars-Sinai Medical Center,
Department of Neurology, Davis Research Building, D-2091, 110 N.
George Burns Road, Los Angeles, CA 90048 USA.
Curr
Pharm Des. 2012 May 11.
Abstract
Stroke
is the 4th leading cause of death and disability in adults in
the USA. However, in the majority of patients, the detrimental
effects of an ischemic insult go untreated because of the lack
of efficacious neuroprotective compounds. Using naturally
occurring compounds as a building block to create efficacious
neuroprotective compounds that cross the blood brain barrier may
eventually benefit the stroke patients. However, historically,
the development of novel compounds has been fraught with
problems including lack of significant pleiotropic activity,
inability to effectively cross the blood brain barrier and poor
bioavailability. This article details, in a stepwise manner, the
synthesis and in vitro screening steps used to produce new
flavonoids that have increased neuroprotective activity compared
to the parent compound fisetin. Moreover, as a preliminary
de-risking step, select compounds have been screened in a
transfected Madin Darby canine kidney cell assay as a measure of
blood brain barrier penetration. Initial de-risking steps have
allowed us to identify a series of BBB-penetrating
neuroprotective candidates for further development.
PMID:
22574983 [PubMed]
http://www.ncbi.nlm.nih.gov/pubmed/22574983
The flavonoid fisetin attenuates
postischemic immune cell infiltration, activation and infarct
size after transient cerebral middle artery occlusion in mice.
Gelderblom
M, Leypoldt F, Lewerenz J, Birkenmayer G, Orozco D, Ludewig P,
Thundyil J, Arumugam TV, Gerloff C, Tolosa E, Maher P, Magnus T.
Source:
Department of Neurology, University Medical Center
Hamburg-Eppendorf, Hamburg, Germany.
J Cereb
Blood Flow Metab. 2012 May;32(5):835-43. doi:
10.1038/jcbfm.2011.189. Epub 2012 Jan 11.
Abstract
The
development of the brain tissue damage in ischemic stroke is
composed of an immediate component followed by an inflammatory
response with secondary tissue damage after reperfusion.
Fisetin, a flavonoid, has multiple biological effects, including
neuroprotective and antiinflammatory properties. We analyzed the
effects of fisetin on infarct size and the inflammatory response
in a mouse model of stroke, temporary middle cerebral artery
occlusion, and on the activation of immune cells, murine primary
and N9 microglial and Raw264.7 macrophage cells and human
macrophages, in an in vitro model of inflammatory immune cell
activation by lipopolysaccharide (LPS). Fisetin not only
protected brain tissue against ischemic
reperfusion injury when given before ischemia but also
when applied 3 hours after ischemia. Fisetin also prominently
inhibited the infiltration of macrophages and dendritic cells
into the ischemic hemisphere and suppressed the intracerebral
immune cell activation as measured by intracellular tumor
necrosis factor α (TNFα) production. Fisetin also inhibited
LPS-induced TNFα production and neurotoxicity of macrophages and
microglia in vitro by suppressing nuclear factor κB activation
and JNK/Jun phosphorylation. Our findings strongly suggest that
the fisetin-mediated inhibition of the inflammatory response
after stroke is part of the mechanism through which fisetin is
neuroprotective in cerebral ischemia.
PMID:
22234339[PubMed - in process] PMCID:
PMC3345911 [Available on 2013/5/1]
http://www.ncbi.nlm.nih.gov/pubmed/22234339
Modulation of multiple pathways involved in
the maintenance of neuronal function during aging by fisetin.
Maher P.
Genes Nutr.
2009 Sep 10.
Source:
The
Salk Institute for Biological Studies, 10010 N. Torrey Pines
Rd., La Jolla, CA, 92037, USA
Abstract
Multiple
factors have been implicated in the age-related declines in
brain function. Thus, it is unlikely that modulating only a
single factor will be effective at slowing this decline. A
better approach is to identify small molecules that have
multiple biological activities relevant to the maintenance of
brain function. Over the last few years, we have identified an
orally active, novel neuroprotective and cognition-enhancing
molecule, the flavonoid fisetin. Fisetin not only has direct
antioxidant activity but it can also increase the intracellular
levels of glutathione, the major intracellular antioxidant.
Fisetin can also maintain mitochondrial function in the presence
of oxidative stress. In addition, it has anti-inflammatory
activity against microglial cells and inhibits the activity of
5-lipoxygenase, thereby reducing the production of lipid
peroxides and their pro-inflammatory by-products. This wide
range of actions suggests that fisetin has the ability to reduce
the age-related decline in brain function.
PMID:
19756810 [PubMed] PMCID:PMC2775892
http://www.ncbi.nlm.nih.gov/pubmed/19756810
NOTE:
Look for research articles about fisetin by Dave R. Schubert
and/or Pamela Maher.
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Known sources:
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Natural sources:
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References:
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Updated: July 2, 2012
Inception: July 2, 2012