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- Cytomegalovirus -
General Information:
Names:
Wikipedia entry:
Dr. Ray Shahelien entry:
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Observations:
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Known sources:
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Natural sources:
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References:
Possible
Origin of Chronic Lymphatic Leukemia Identified
ScienceDaily (Apr. 11, 2012)
...they were able to identify the protein pUL32 of the human cytomegalovirus...The
cytomegalovirus, a member of the herpes family of viruses...
http://www.sciencedaily.com/releases/2012/04/120411084040.htm
Treatment of Common Virus Can
Reduce Tumour Growth, Study Suggests
ScienceDaily (Sep. 27, 2011)
http://www.sciencedaily.com/releases/2011/09/110927072612.htm
Detection of human cytomegalovirus
in medulloblastomas reveals a potential therapeutic target.
Baryawno N, Rahbar A, Wolmer-Solberg N, Taher C, Odeberg J,
Darabi A, Khan Z, Sveinbjörnsson B, FuskevÅg OM, Segerström L,
Nordenskjöld M, Siesjö P, Kogner P, Johnsen JI,
Söderberg-Nauclér C.
J Clin Invest. 2011
Oct;121(10):4043-55. doi: 10.1172/JCI57147. Epub 2011 Sep 26.
Source: Karolinska
Institutet, Department of Women's and Children's Health,
Childhood Cancer Research Unit, Stockholm, Sweden.
Abstract
Medulloblastomas are the most common malignant brain tumors in
children. They express high levels of COX-2 and produce PGE2,
which stimulates tumor cell proliferation. Human cytomegalovirus
(HCMV) is prevalent in the human population and encodes proteins
that provide immune evasion strategies and promote oncogenic
transformation and oncomodulation. In particular, HCMV induces
COX-2 expression; STAT3 phosphorylation; production of PGE2,
vascular endothelial growth factor, and IL-6; and tumor
formation in vivo. Here, we show that a large proportion of
primary medulloblastomas and medulloblastoma cell lines are
infected with HCMV and that COX-2 expression, along with PGE2
levels, in tumors is directly modulated by the virus. Our
analysis indicated that both HCMV immediate-early proteins and
late proteins are expressed in the majority of primary
medulloblastomas. Remarkably, all of the human medulloblastoma
cell lines that we analyzed contained HCMV DNA and RNA and
expressed HCMV proteins at various levels in vitro. When
engrafted into immunocompromised mice, human medulloblastoma
cells induced expression of HCMV proteins. HCMV and COX-2
expression correlated in primary tumors, cell lines, and
medulloblastoma xenografts. The antiviral drug valganciclovir
and the specific COX-2 inhibitor celecoxib prevented HCMV
replication in vitro and inhibited PGE2 production and reduced
medulloblastoma tumor cell growth both in vitro and in vivo.
Ganciclovir did not affect the growth of HCMV-negative tumor
cell lines. These findings imply an important role for HCMV in
medulloblastoma and suggest HCMV as a novel therapeutic target
for this tumor.
Comment in: Viruses and human brain tumors: cytomegalovirus
enters the fray. [J Clin Invest. 2011]
PMID: 21946257 [PubMed] PMCID: PMC3195466
Full Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195466/?tool=pubmed
http://www.ncbi.nlm.nih.gov/pubmed/21946257
Shark Compound Proves Potential as
Drug to Treat Human Viruses, Says Researcher
ScienceDaily (Sep. 20, 2011)
...In animal studies, his collaborators discovered that
squalamine controlled infections of yellow fever, Eastern equine
encephalitis virus, and murine cytomegalovirus,
and in some cases cured the animals...
http://www.sciencedaily.com/releases/2011/09/110919151306.htm
Squalamine as a broad-spectrum
systemic antiviral agent with therapeutic potential.
Zasloff M, Adams AP, Beckerman B, Campbell A, Han Z, Luijten E,
Meza I, Julander J, Mishra A, Qu W, Taylor JM, Weaver SC, Wong
GC.
Proc Natl Acad Sci U S
A. 2011 Sep 20;108(38):15978-83. Epub 2011 Sep 19.
Source: Transplant
Institute, Department of Surgery, Georgetown University Medical
Center, Washington, DC 20007, USA.
Erratum in Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):18186.
Abstract
Antiviral compounds that increase the resistance of host tissues
represent an attractive class of therapeutic. Here, we show that
squalamine, a compound previously isolated from the tissues of
the dogfish shark (Squalus acanthias) and the sea lamprey
(Petromyzon marinus), exhibits broad-spectrum antiviral activity
against human pathogens, which were studied in vitro as well as
in vivo. Both RNA- and DNA-enveloped viruses are shown to be
susceptible. The proposed mechanism involves the capacity of
squalamine, a cationic amphipathic sterol, to neutralize the
negative electrostatic surface charge of intracellular membranes
in a way that renders the cell less effective in supporting
viral replication. Because squalamine can be readily synthesized
and has a known safety profile in man, we believe its potential
as a broad-spectrum human antiviral agent should be explored.
Comment in: Shark compound bites back against viruses. [Future
Med Chem. 2011]
PMID: 21930925 [PubMed] PMCID: PMC3179074
http://www.ncbi.nlm.nih.gov/pubmed/21930925
Full Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179074/?tool=pubmed
High Blood Pressure Could Be
Caused By A Common Virus, Study Suggests
ScienceDaily (May 16, 2009) — A new study suggests for the first
time that cytomegalovirus (CMV), a common viral infection
affecting between 60 and 99 percent of adults worldwide, is a
cause of high blood pressure, a leading risk factor for heart
disease, stroke and kidney disease...
http://www.sciencedaily.com/releases/2009/05/090514221915.htm
http://www.bidmc.org/News/InResearch/2009/May/CMVandBloodPressure.aspx
Human cytomegalovirus
infection is a novel etiology for essential hypertension.
Zhang M, Yang Y, Yang X, Cai J.
Med Hypotheses. 2011
May;76(5):682-4. Epub 2011 Feb 12.
Source: Department of
Cardiology, Chaoyang Hospital, Capital Medical University,
Beijing 100010, China.
Abstract
...Based on current studies, we present a hypothesis that human
cytomegalovirus is an opportunistic pathogen that causes
essential hypertension by disrupting nitric oxide synthesis and
immune defense and by activating inflammation and the
renin-angiotensin system.
PMID: 21316863 [PubMed]
http://www.ncbi.nlm.nih.gov/pubmed/21316863
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Updated: July 25, 2012
Inception: July 25, 2012