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- CCSVI -
General Information:
Names:
Wikipedia entry:
Dr. Ray Shahelien entry:
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Observations:
CCSVI chronic
cerebrospinal
venous insufficiency
See also Multiple Sclerosis
(MS)
Inflammation
NPH
Dr. Paolo Zamboni, a professor
of medicine at the University of Ferrara in Italy appears to have
found a connection between iron accumulation and multiple
sclerosis (MS). This accumulation of iron in the brain is
due to a reduced flow of blood in the vessels that drain blood
from the brain. He hypothesized that iron damages the blood
vessels and allows the metal, along with other unwelcome cells, to
cross the brain-blood barrier. Combine this with the "Iron
metabolism in Parkinsonian syndromes" article above, and we have
the intriguing idea that perhaps Parkinsonian syndromes
are also caused by blood circulation problem.
Researcher's labour of love leads to
MS breakthrough
André Picard and Avis Favaro
From Saturday's Globe and Mail Published on Friday, Nov. 20, 2009
9:07PM EST Last updated on Tuesday, Dec. 15, 2009 9:20PM EST
Elena Ravalli was a seemingly healthy 37-year-old when she began
to experience strange attacks of vertigo, numbness, temporary
vision loss and crushing fatigue. They were classic signs of
multiple sclerosis, a potentially debilitating neurological
disease.
It was 1995 and her husband, Paolo Zamboni, a professor of
medicine at the University of Ferrara in Italy, set out to help.
He was determined to solve the mystery of MS – an illness that
strikes people in the prime of their lives but whose causes are
unknown and whose effective treatments are few.
What he learned in his medical detective work, scouring dusty old
books and using ultra-modern imaging techniques, could well turn
what we know about MS on its head: Dr. Zamboni's research suggests
that MS is not, as widely believed, an autoimmune condition, but a
vascular disease.
Fighting for
his wife's health, Dr. Zamboni looked for answers in the medical
literature. He found repeated references, dating back a century,
to excess iron as a possible cause of MS. The heavy metal can
cause inflammation and cell death, hallmarks of the disease. The
vascular surgeon was intrigued – coincidentally, he had been
researching how iron buildup damages blood vessels in the legs,
and wondered if there could be a similar problem in the blood
vessels of the brain.
Using ultrasound to examine the vessels leading in and out of the
brain, Dr. Zamboni made a startling find: In more than 90 per cent
of people with multiple sclerosis, including his spouse, the veins
draining blood from the brain were malformed or blocked. In people
without MS, they were not.
He hypothesized that iron was damaging the blood vessels and
allowing the heavy metal, along with other unwelcome cells, to
cross the crucial brain-blood barrier. (The barrier keeps blood
and cerebrospinal fluid separate. In MS, immune cells cross the
blood-brain barrier, where they destroy myelin, a crucial
sheathing on nerves.)
More striking still was that, when Dr. Zamboni performed a simple
operation to unclog veins and get blood flowing normally again,
many of the symptoms of MS disappeared. The procedure is similar
to angioplasty, in which a catheter is threaded into the groin and
up into the arteries, where a balloon is inflated to clear the
blockages. His wife, who had the surgery three years ago, has not
had an attack since.
The researcher's theory is simple: that the underlying cause of MS
is a condition he has dubbed “chronic cerebrospinal venous
insufficiency.” If you tackle CCSVI by repairing the drainage
problems from the brain, you can successfully treat, or better
still prevent, the disease...
First Blinded Study of Venous
Insufficiency Prevalence in Multiple Sclerosis Shows Promising
Results
ScienceDaily (Feb. 14, 2010) — More than 55 percent of multiple
sclerosis patients participating in the initial phase of the first
randomized clinical study to determine if persons with MS exhibit
narrowing of the extracranial veins, causing restriction of normal
outflow of blood from the brain, were found to have the
abnormality... These preliminary results are based on the first
500 participants in the Combined Transcranial and Extracranial
Venous Doppler Evaluation (CTEVD) study, which began at UB in
April 2009. Investigators are planning to examine 500 additional
subjects, who will be assessed in the second phase of the study
with more advanced diagnostic tools. Complete data on the first
500 will be presented at the American Academy of Neurology meeting
in April. Robert Zivadinov, MD, PhD, UB associate professor of
neurology and principal investigator on the study, says he is
"cautiously optimistic and excited" about the preliminary data.
Zivadinov directs the Buffalo Neuroimaging Analysis Center (BNAC),
located in Kaleida Health's Buffalo General Hospital, where the
study is being conducted... The investigation is the first step in
determining if a condition called chronic cerebrospinal venous
insufficiency (CCSVI) is a major risk factor for MS. CCSVI is a
complex vascular condition discovered and described by Paolo
Zamboni, MD, from Italy's University of Ferrara. Zamboni's
original investigation in a group of 65 patients and 235 controls
showed CCSVI to be associated strongly with MS, increasing the
risk of having MS by 43 fold. Zamboni and Zivadinov hypothesize
that this narrowing restricts the normal outflow of blood from the
brain, resulting in alterations in the blood flow patterns within
the brain that eventually cause injury to brain tissue and
degeneration of neurons.
http://www.sciencedaily.com/releases/2010/02/100210110744.htm
One has to wonder what other
diseases CCSVI could cause? (See more at Irony of Iron)
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Known sources:
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Natural sources:
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References:
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Updated: July 2, 2012
Inception: July 2, 2012