B-Complex Vitamins

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- B-Complex Vitamins -

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Observations:

B-Complex Vitamins

See also B6
         B9
         B12
         Niacinamide

Recommended dosages gleaned from the articles cited below:

B-Vitamin Trio:
vitamin B6 (pyridoxine HCl)     - 20mg
vitamin B9 (folate or folic acid) - 0.8mg (= 800 mcg.)
vitamin B12 (cyanocobalamin)      - 0.5mg (= 500 mcg.)

Here in the U.S., I found "Tri-B" from Carlson. It has 25mg B-6, 800mcg B9, 400mcg B-12. Close enough for me!

B vitamins found to halve brain shrinkage in old
Wed Sep 8, 2010 5:01pm EDT

LONDON (Reuters) - Daily tablets of large doses of B vitamins can halve the rate of brain shrinkage in elderly people with memory problems and may slow their progression toward dementia... The pills, called "TrioBe Plus" contained around 300 times the recommended daily intake of B12, four times daily advised folate levels and 15 times the recommended amount of B6...
http://www.reuters.com/article/idUSTRE6875CL20100908

B-Complex Vitamins May Help Slow Progression of Dementia
ScienceDaily (Oct. 27, 2010)
Large doses of B-complex vitamins could reduce the rate of brain shrinkage by half in elderly people with memory problems and slow the progression of dementia.
http://www.sciencedaily.com/releases/2010/10/101027155126.htm

Vitamin B treatment could delay onset of Alzheimer's - study
Published Date:08 September 2010
The research, published in the online journal Public Library of Science ONE, is controversial because it defies current scientific dogma about the way to tackle Alzheimer's...
http://www.yorkshireeveningpost.co.uk/news/Vitamin-B-treatment-could-delay.6520596.jp

10p pill to beat Alzheimer's disease: Vitamin B halts memory loss in breakthrough British trial
By Fiona Macrae
Last updated at 12:12 PM on 9th September 2010

The breakthrough centres on a compound called homocysteine which is naturally made in the body and, at high levels, has been linked to memory loss and Alzheimer's... Vitamin B is known to break down homocysteine, so the researchers decided to look at whether giving patients the vitamin would be good for memory... High dose vitamins may trigger cancer and are known to fuel existing cancers. They may also react with medicines including arthritis and psoriasis drugs. Despite this, Professor Smith says he ‘would not hesitate’ to take the cocktail of 20mg of vitamin B6, 0.8mg of vitamin B9, or folate, and 0.5mg of vitamin B12, himself, if he were diagnosed with MCI.
http://www.dailymail.co.uk/health/article-1310330/Vitamin-B-halts-memory-loss-10p-pill-beat-Alzheimers-disease.html

Read more: http://www.dailymail.co.uk/health/article-1310330/Vitamin-B-halts-memory-loss-10p-pill-beat-Alzheimers-disease.html#ixzz0zOqfSHaZ

Homocysteine-Loweringby B Vitamins Slows the Rate of Accelerated Brain Atrophy in Mild Cognitive Impairment: A Randomized Controlled Trial
A. David Smith1, Stephen M. Smith, Celeste A. de Jager, Philippa Whitbread, Carole Johnston, Grzegorz Agacinski, Abderrahim Oulhaj, Kevin M. Bradley, Robin Jacoby, Helga Refsum

Results

A total of 168 participants (85 in active treatment group; 83 receiving placebo) completed the MRI section of the trial. The mean rate of brain atrophy per year was 0.76% [95% CI, 0.63–0.90] in the active treatment group and 1.08% [0.94–1.22] in the placebo group (P = 0.001). The treatment response was related to baseline homocysteine levels: the rate of atrophy in participants with homocysteine >13 µmol/L was 53% lower in the active treatment group (P = 0.001). A greater rate of atrophy was associated with a lower final cognitive test scores. There was no difference in serious adverse events according to treatment category...

The treatment group received oral TrioBe Plus® (Meda AB/Recip AB, Box 906, Pipers väg 2A, SE-170 09 Solna, Sweden) containing 0.8 mg folic acid, 0.5 mg cyanocobalamin and 20 mg pyridoxine HCl, or a placebo.
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0012244

B Vitamins Slow Brain Atrophy in People With Memory Problems
ScienceDaily (Sep. 12, 2010) — Daily tablets of certain B vitamins can halve the rate of brain shrinkage in elderly people who suffer from mild memory problems, an Oxford University study has shown... The team found that on average the brains of those taking the folic acid, vitamin B6 and B12 treatment shrank at a rate of 0.76% a year, while those in the placebo group had a mean brain shrinkage rate of 1.08%. People with the highest levels of homocysteine benefited most, showing atrophy rates on treatment that were half of those on placebo...
http://www.sciencedaily.com/releases/2010/09/100912213050.htm

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