www.perpetualcommotion.com
"Give
with a free hand, but give only your own."
-- J.R.R.
Tolkien The Children of Hurin
- Aluminum -
General
Information:
Names:
Wikipedia entry:
Dr. Ray Shahelien entry:
********************************************************************************************
Observations:
I found this paper on the effects of aluminum and tau formation in a rat study.
Do aluminium and/or glutamate induce Alz-50 reactivity?
"...These
results
suggest: (1) aluminium enters neurons and (2) aluminium alone
induces possible conformational changes in tau as detected by
the
Alz-50 antibody, while aluminium combined with glutamate, or
glutamate alone, do not."
PMID: 9530999 [PubMed]
and,
http://www.springerlink.com/content/m756l301187u1j84/
I wonder if it possible to have "aluminum poisoning"? I mean, if you somehow ingest too much aluminum, does it stick around like lead and mercury? I wonder if there is a way to flush it out. Also, I wonder if the presence of some other metal, such as mercury or lead or copper, could interfere with normal aluminum elimination processes, leading to excess aluminum, and therefore tau problems.
********************************************************************************************
Known
sources:
********************************************************************************************
Natural
sources:
********************************************************************************************
References:
Aluminum:
Would
decreased aluminum ingestion reduce the incidence of
Alzheimer's
disease?
D. R.
McLachlan, T. P. Kruck, W. J. Lukiw and S. S. Krishnan
Department
of Medicine, University of Toronto, Ont.
Canadian Medical
Association Journal, Vol 145, Issue 7
793-804
http://www.cmaj.ca/cgi/content/abstract/145/7/793?ijkey=081a09c7510999dd7673698216156e4e81449c1d&keytype2=tf_ipsecsha
Alzheimer's
Disease: A Treatment Strategy
"I
wrote this paper for my dad, who may have Alzheimer's Disease.
It is
the result of about 100 hrs work on medline and at the
biomedical
library."
http://www.bio.net/bionet/mm/ageing/1995-January/001003.html
2.4.
Aluminum chelation therapy
"The
potential therapeutic capacity of
chelation
of aluminum for AD was
demonstrated
[50]. A low dose of the injectable
desferrioxamine was used to re- move about a third of the
aluminum
(from 4.09 ug/g to 2.69 ug/g) from the brains of elderly AD
patients
over two years. The trial slowed the disease process
for
the entire group by an average of 50 percent. Some good
responder
patients were benefited for up to five years [51]. Deaths
mostly from pneumonia were dra- matically reduced from 9 in the
untreated group to only 1 in the treatment group."
[Discusses
oral chelation
therapy]
http://www.deptplanetearth.com/pub/jad3jansson_p7.html
ALUMINUM
AND ALZHEIMER’S DISEASE: CONTRADICTION AND
PARADOX
SUMMARY
"The
Aluminum Hypothesis of Alzheimer’s disease began in 1965 with
the demonstration that aluminum salts injected into the rabbit
brain
induced neurofibrillary tangles. Since this initial
report,
there has been considerable basic, clinical and epidemiological
research conducted to evaluate the biological plausibility of
aluminum’s purported etiological role in Alzheimer’s
disease. Presently there is a widespread belief among the
general public that aluminum plays some role in Alzheimer’s
while, in contrast, a dwindling number of scientists continue to
explore the link between this metal and the development of this
disease. The present paper reviews the scientific
literature
concerning the Aluminum Hypothesis and discusses the possible
reason
for the general lack of interest in the Aluminum Hypothesis
among
mainstream
scientists."
http://www.world-aluminium.org/news/montreal/lidsky.htmhttp://drcranton.com/chelation/EDTA_Mysteries.htm
Aluminosilicate
Precipitation and Alzheimer's Disease
"The
epidemiological features of both diseases can be explained using
the
hypothesis that the initiating factor is the precipitation of
aluminosilicates in the brain. The combination of solubilized
aluminum and the only water-soluble form of silicon, silicic
acid, to
form insoluble aluminosilicates is a peculiar and unique
reaction in
inorganic chemistry. An evaluation of the uptake and
distribution of
these compounds provides an explanation for the development of
plaques and tangles and a rationale for the findings of the
collective epidemiological
studies."
http://www.alzforum.org/res/adh/cur/meyer/default.asp
Aluminium
and the pathogenesis of senile plaques: studies in Alzheimer's
disease and chronic renal failure
J.
A. Edwardson1 and J. M. Candy1
(1) MRC Neurochemical
Pathology Unit, Newcastle General Hospital, NE4 6BE Newcastle
upon
Tyne, UK
"Abstract Aluminium and silicon are
co-localised as aluminosilicate at the centre of the senile
plaque
core. These focal deposits appear to be a consistent and
specific
feature associated with A4 amyloid fibrils in the plaque core
and are
not associated with other types of amyloidosis. A pathogenic
role for
AI and Si is suggested by the finding of A4 amyloid deposits,
immature senile plaques and an abnormal content and distribution
of
these elements in the brains of patients (<55 years) with
chronic
renal failure. Evidence suggests that AI uptake and distribution
within the brain is mediated by transferrin. The distribution of
transferrin receptors may account for the vulnerability of
regions
such as the hippocampus and cortex which are selectively
involved in
Alzheimer's
disease."
http://www.springerlink.com/(i4qyhi45tnr5jyyi0ojlpbmx)/app/home/contribution.asp?referrer=parent&backto=issue,17,27;journal,63,101;linkingpublicationresults,1:100162,1
Aluminum
neurotoxicity in mammals
H.
M. Wisniewski1, R. C. Moretz1, J. A. Sturman2, 1, G. Y. Wen1 and
J.
W.
Shek1
(1) Institute for Basic Research in
Developmental Disabilities, Departments of Pathological
Neurobiology,
New York State Office of Mental Retardation and Developmental
Disabilities, USA
(2) Developmental Biochemistry, 1050
Forest Hill Road, 10314 Staten Island, New York, USA
Abstract
"Although aluminum comprises a large
percentage of the Earth's crust, it is excluded from body
tissues,
and especially from the central nervous system. When aluminum is
experimentally introduced to the central nervous system, several
neurotoxic effects are observed:i.e. neurofibrillary changes,
behavioral and cognitive deficits and enzymatic and
neurotransmitter
changes, as well as certain types of epileptic seizures."
"The
localization of relatively high levels of aluminum in Alzheimer
disease, Guamanian amyotrophic lateral sclerosis and
Parkinsonism-dementia has led to the implication of aluminum as
a
pathogenic factor in these diseases. Recent studies have shown
that
microtubule-associated proteins are part of the paired helical
filaments which make up the intraneuronal neurofibrillary
tangle.
Other studies have identified the protein making the vascular
and
neuritic (senile) plaque amyloid and located the gene
responsible for
this protein to chromosome 21."
"Our electron microprobe
analysis studies have not found the levels of aluminum or
silicon in
either the neurofibrillary tangles or amyloid cores reported
elsewhere, nor have the levels of aluminum been elevated in
approximately one half of the tangles and plaque cores examined
to
date."
http://www.springerlink.com/(watzas55ogiewy55llfqhl45)/app/home/contribution.asp?referrer=parent&backto=issue,20,27;journal,63,101;linkingpublicationresults,1:100162,1
Precipitation
and characterization of an aluminosilicate from
AlCl3-Na2SiO3-HCl
in serum, of interest for Alzheimer disease.
Bilinski
H, Horvath L, Trbojevic-Cepe M.
Ruder Boskovic Institute,
Zagreb, Croatia.
"A precipitation experiment was
performed with human serum to model aluminosilicate formation in
brains of patients with Alzheimer disease. Aluminum and (or)
silicate
ions were added to serum in a 1:2 molar ratio at pH 7.4.
Precipitates
formed immediately and were left for 24 h at 37 degrees C before
filtration. Silicate and aluminosilicate formed
precipitates with
human serum proteins albumin, transferrin, and IgG. In untreated
samples, the IgG/albumin ratio increased slightly compared with
the
ratio in dried serum. Diethylbarbiturate-washed precipitates had
a
significantly lower protein content than did untreated ones. The
IgG/albumin ratio increased considerably in the sample
containing
aluminosilicate. We conclude that IgG is the sodium dodecyl
sulfate-soluble human protein most firmly bound to the
aluminosilicate matrix. From 27Al magic-angle-spinning nuclear
magnetic resonance (MAS NMR), a pronounced peak was found at
52.79
ppm and a minor peak at 0.53 ppm, suggesting that 4-coordinated
aluminum predominates and that
6-coordinated aluminum is present
in a smaller proportion. The 29Si MAS NMR spectrum shows a
poorly
ordered structure. The aluminosilicate formed also contains the
cations Na+ > K+ > Ca2+ > Mg2+ and anions Cl- >
PO4(3-).
Rather than looking for aluminum toxicity to explain the effects
of
Alzheimer disease, one should consider that by precipitating
such a
composite phase, the balance of cations, anions, and proteins in
human serum is changing."
PMID: 1394986 [PubMed - indexed
for MEDLINE]
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1394986&dopt=Abstract
********************************************************************************************
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
Home
Preface Brain
Failure Notes Notes
II References pg. 1 References
pg. 2
Nutritional
Alternatives Patricia's
Protocol Tauopathy
Discussion
Forum
Correspondence
Newsletters Poems
Memory Enhancement
********************************************************************************************
Questions or comments, contact "perpetualcommotion.com" at gmail.com
Updated: July 2,
2012
Inception: July 2, 2012