"Give with a free hand, but give only your own."
 -- J.R.R. Tolkien The Children of Hurin

I have nothing to sell you but hope, and that I give you for free.

Dedicated to the memory of my mother Patricia, who I couldn't save because I didn't know.
What I do know, I give to you.
Please save someone.

The Distillery
(In other words, "I found it interesting, but haven't had the time to catagorize it yet.)

The PC Reading List

Message Boards & Blogs
Web Sites
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                     namely PSP, MSA, CBD, and LBD]
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[Reg. req., Tone:  Death club]
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Alzheimer Research Forum
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Dr. Mary Newport
The Alzheimer Library

Unlike Jean Carper who listed 100 Simple Things You Can Do to Prevent Alzheimer's and Age-Related Memory Loss, I don't know how many things I have listed in my Web pages.  Probably dozens.  But, my list is free!

Think outside the box!

Some things to ask the doctor about...
(Study these things. Follow the links below for backup information.  Go to the original research papers or news articles. Print out the information you are interested in, read it, and take it with you the next time you see your physician.)

I.      Potentially treatable conditions that may mimic the symptoms of dementia, Parkinson's
        disease, Alzheimer's disease, corticobasal degeneration (CBD), etc.

        1) NPH (Normal Pressure Hydrocephalus)
        2) Lyme Disease
        3) Helicobacter pylori infection
        4) Celiac disease (gluten metabolism) [EDIT NOTE:  NEED LINKS TO MORE DISCUSSION OF THESE]
        5) Sleep apnea
        6) Cold sore virus (HSV-1, Herpes Simplex Virus-1), see Lauric Acid, Acyclovir
        7) Vitamin B12 deficiency
        8) CCSVI - Chronic CerebroSpinal Venous Insufficiency
        9) Carotid artery disease (Carotid stenosis)
        10) Neurospirochetosis - Invasion of the brain by spirochete bacteria such as Periodontal
            pathogen Treponemas (T. pectinovorum, T. amylovorum, T. lecithinolyticum, T. maltophilum,
            T. medium, T. socranskii) and Borrelia burgdorferi (Lyme disease)

II.     Substances found in nature that have shown promise in relieving the
        symptoms or even the causes of neurodegenerative diseases

        1) Ginkgo-biloba
        2) Scyllitol - Dissolves amyloid beta (AB) plaques and restores
                       mental abilities in transgenic mice (standard "animal model"
                       for AD research).  Most abundant plant source is the coconut palm.
        3) Curcumin -
(a.k.a. turmeric extract) Similar effect as scyllitol in "standard
                        animal model"
                      plus other positive effects.
        4) Phosphatidylserine (PS)
        5) Huperzine A
        6) Vinpocetine
        7) Cinnamon -  Inihibits tau protein hyperphosphorylation & untangles
                       tau fibers that have already formed.
        8) Niacinamide - Inibits tau protein corruption, reduces quantity of
                         tau protein aggregations.
        9) MCT - "Medium-chain Triglycerides" provides an alternate energy source for
                 neurons which have trouble metabolising glucose.  Coconut oil is rich
                 in several MCTs.
       10) Adaptation of The Sinatra Solution to neurodegenerative diseases with
           glucose hypometabolismCoenzyme Q10 (CoQ10), L-carnitine (or maybe
           acetyl-L carnitine), D-ribose and magnesium to improve production of ATP by
           neuronal mitochondria

       11) Alpha-lipoic Acid - Antioxidant, supports mitochondrial function, may halt
                               the progression of AD.

       12) Grape Seed Extract -  Inihibits tau protein hyperphosphorylation & untangles
                                 tau fibers that have already formed. [?]

       13) Aphanizomenon flos-aquae (AFA) - May halt progression of AD and related
                                            neurodegenerative diseases for as long as
                                            three years, 6 month improvement period.

       14) Colostrinin - Shows promise in slowing progression of AD.

       15) Apple Juice - May inhibit amyloid beta of Alzheimer's disease

       16) Rosemary - May have compounds that prevent the breakdown of acetylcholine.

       17) Green Tea (
EGCG, epigallocatechin gallate) - Inhibits alpha-synuclein and
           amyloid-beta fibrillogenesis,
higher consumption of green tea was associated
           with a lower prevalence of cognitive impairment.
       18) Anatabine - Reduces "brain inflammation".  A component of tobacco.

       19) Trehalose - Promotes autophagy

       20) Fisetin - Neuroprotective Blood Brain Barrier Penetrating Flavonoid

       21) Coffee - 3 or 4 cups per day appears to prevent or at least delay progression of
           MCI (Mild Cognative Impairment) to AD.

III.    Dietary changes to improve artery disease and reduce the chance of strokes
        See McDougall and Mirkin

        1) Improve circulation, reverse artery disease
        2) In combination with statin drugs
        3) Increase scyllitol intake from grains and legumes

IV.     Drugs currently on the market that have been shown to slow the progression of
        neurological disease

        1)  Memantine (a.k.a. Namenda: AD)
        2)  Enbrel (Etanercept:  AD)
        3)  Lithium (ALS, tauopathies?)
        4)  Methylene blue (tauopathies)
        5)  Simvastatin (Zocor:  Parkinson's)
Desferrioxamine (intramuscular)-- chelates iron, aluminum.  Halts
            AD progression.
        7)  Deferasirox (oral)-- chelates iron, probably others.  Possible
            alternative to desferrioxoxamine.

        8)  Clioquinol - pre-occupies AB metal ion binding sites, halts AD
        9)  Lisinopril - (For MS)
        10) Actos - mitochondrial dysfunction of Parkinson's Disease
        11) Metformin - tauopathies
        12) Gleevec - In mouse studies, "the drug dramatically reduced beta amyloid not
            only in the blood, but also in the brain where the drug cannot penetrate."

        13) Zileuton - an FDA approved drug used to treat asthma can reduce the formation

            of amyloid beta.

        14) Tetracycline - Disassemble amyloid beta, suppress or eliminate spirochete

            of the brain.

        15) Doxycycline - suppress or eliminate spirochete of the brain.
        16) Bexarotene (AD/amyloid beta: A drug used to treat a type of skin cancer called
                         cutaneous T-cell lymphoma.)
Epothilone D (Epo-D) 

V.      Mechanical devices that show promise in arresting the progression of

        1) COGNIShunt [proven ineffective?]
        2) Infrared
        3) RF
        4) Angioplasty (see more at CCSVI)

VI.     Metals involved with neuro-degenerative diseases
Aluminum and Aluminosilicates
        3) Iron metabolism
in Parkinsonian Syndromes

VII.    Chelation agents that can be taken orally
        - to open up arteries
        - remove metal ions that may cause nerve cell damage
        - remove metal ions that may cause normally harmless (even crucial)
          proteins present in the brain to become toxic by a catalytic
          action (amyloid beta plaques)
        - remove metals from the body.  It is not known for sure if this
          causes or exacerbates AD, but the cost is very low, and the risk
          of adversely affecting your health is low.  At the worst, they
          will be ineffective.

        1) Phytic Acid (myo-inositol hexakisphosphate, IP6, InsP6) Naturally
           occurring "anti-nutrient" that binds to free metal ions, allowing
           the body to flush them out.
Oral EDTA.  EDTA is a common food additive used to preserve the
           flavor and color of processed foods.  Perhaps it can be found in
           bulk, since food processing companies must use it in this way

Cilantro:  An herb found to mobilize aluminum, mercury and some
           other metals that are then chelated by a chelating agent such as
           phytic acid or EDTA.  Cheap and easily available.
        4) Curcumin:  Curcumin, amoung its other salubrious qaulities, is a
           powerful iron and copper chelator.

IIV.    Do blood thinners and anti-platelet medications reduce the risk of
        strokes and therefore the worsening of vascular dementia?

        1) Aspirin (reports of developing aspirin resistance?)
        2) Cumadin, etc (brand name or generic pharmaceuticals)

IX.     Are there any natural blood thinners and anti-platelets?
        -to prevent ischemic strokes (can exacerbate hemorrhagic strokes)

        -Natural blood thinners
         a. Garlic
         b. Ginkgo-biloba  

X.      Have statin drugs used to reduce cholesterol levels been found to
        slow the progression of Alheimer's disease or reduce the the risk
        strokes by reversing arterial sclerosis?
        - Statins - lowers cholesterol, delays AD progression.

XI.     Are there any alternative therapies available?
        - IV EDTA chelation therapy-- chelates most metals.  Reported by
          chelation therapists to halt and reverse AD symptoms.
        - Infrared (1072nm)

Nutritional alternatives:  Things you can try while coaxing the physicians to get off their butts and try something. [EDIT NOTE:  THE NUTRITIONAL ALTERNATIVES PAGES IS OUT OF DATE AND NEEDS MUCH UPDATING]

"First Aid" for AD Sundowning:
1 cup apple juice (or non-alcoholic apple cider) 2 times per day
20g of MCT oil from coconut meat, coconut oil, or refined "MCT oil".
    - 2 "Mounds" candy bars, or
    - 2x2" square of fresh coconut meat, or
    - 3 coconut macaroons, or
    - "coconut milk" as sold for Thai cooking (quantity TBD), or
    - 7 tsp. of "MCT oil", as sold for bodybuilding
    - 500mg capsules 2x per day, or
    - 1 Tbsp unrefined ground turmeric spice 2x per day, or
    - Curry dishes, at least 3x per week

See also Prazosin

The purpose of this web site is to help my mother and is an educational service to others.  I needed a way to keep track of the mountains of information I was digging up on the various neurological diseases she has been diagnosed with by the various physicians she has seen.  So, I started to put it on this web page for my own use, and that of my family.  It is literally my electronic notebook, which I am constantly updating, revising, correcting, and expanding.  Perhaps you can also gather some information from all this for when you meet with a physician to discuss what can be done for someone suffering from brain failure:  Alzheimer's disease (AD), Vascular Dementia (VD), Normal Pressure Hydrocephalus (NPH), or any of the Parkinsonian Syndromes such as corticobasal degeneration (CBD) or progressive supranuclear palsy (PSP).  You will have a list of questions to ask, and sources to read so that you will know what to ask.

The real challenge may be...

Even if you find something in these pages you think might work, and the doctors agree with it, the real challenge might be getting the patient to change their lifestyle.  Habbits and behavior will probably be your greatest obstacle.  This is like watching your grandfather smoke himself to death with cigarettes.  You know they are bad for him, and that he is smoking way way too much.  But what can you do?  There really just isn't a way to stop someone hell-bent on self destruction, so you must just stand there helpless watching him pound nails in his own coffin.  A person who is starting to show the signs of Brain Failure (dementia, Alzheimer's Disease, Vascular Dementia, NPH, etc.), may not even be physically or mentally able to help themselves.  They may not have an appetite to eat better food.  They may not be able to swallow pills or feed themselves.  Their primary caregiver may not believe that mere lifestyle and eating habbits and herbs and medicine or anything can help.  Fatalism or a state of denial on the part of the caregiver can doom the dementia sufferer to an inevitable decline.  The only way pills can help you, if they can, is if you have enough faith to swallow them.

This may be your greatest challenge.  This, more than anything else, you may not be able to overcome.

June 13, 2012
As I walk through the nursing home to visit my father, I pass by so many elderly people, most of whom are there because their minds are failing and they just can't take care of themselves any more.  I know things, things I have presented to you here.  It breaks my heart to see people that I believe I could help just by telling someone of the things I know.  But I can't.  They would think me crazy.

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You can reach me by mai|ing to "perpetualcommotion.com", at gmail dot com.

Updated November 27, 2010
Inception June 5, 2006

A "Death Club" refers to an on-line community, such as a message board or discussion group that is obsessed with death at the ultimate solution-- the final solution-- to all the problems of life.  It is a collection of people who, at best, seek to find justification for inaction that will expedite the demise of someone who has become an emotional or physical drain on them.  At worst, they want to actively hurry things along.  The "Club" provides support for actions that would cause a burdened conscience.  This is a form of "collective salvation".  Unfortunately, people must face judgment as individuals, not as a member of a group.  And even if a group approves, this does not remove guilt, as former members of the German National Socialist party (Nazi) came to realize. With regard to Internet discussion groups, "death club" means that the topics of discussion are dominated by people who regard death of other people as the ultimate solution to all their problems, and push an agenda of depression and hopelessness.

Alz.org's "Medications and Treatments" forum
In December of 2011, the Alzheimer's Association remove the "Medications and Treaments for Alzheimer's Disease" discussion forum.  This is truly sad development since that was one of the most informative discussion groups for AD I have found.  I have not found an alternative, other than to steer people to the Yahoo Group "Tauopathies" (See the link above).  There is (for the time being) a link to an archive of the posts to that board available.