“Give with a free hand, but give only your own.” - J.R.R. Tolkien
see also Niacinamide, Nicotinamide
Wikipedia entry: https://en.wikipedia.org/wiki/Nicotinamide_riboside
NOTE: Both Nicotinamide Mononucleotide (NAM) and Nicotinamide Riboside may be metabolized to NAD+
Riboside Promotes Sir2 Silencing and Extends Lifespan via Nrk and
Urh1/Pnp1/Meu1 Pathways to NAD+
Peter Belenky, Frances G. Racette, Katrina L. Bogan, Julie M. McClure, Jeffrey S. Smith, * and Charles Brenner,
Nicotinamide Mononucleotide (NMN) is a combination of nicotinamide (niacinamide) and ribose, according to Wikipedia. Both of these are available as supplements. Also, “nicotinamide riboside” is available from supplement distributors, and it isn’t too expensive.
YOU choose to live forever? Age-reversing pill that Nasa wants to
give to astronauts on Mars will begin human trials within six
Scientists have discovered a key signalling process in DNA repair
They have used this process in the development of a drug to reverse ageing
Trials on mice found that the pill repaired DNA damage after a week
Nasa wants the new technology to protect its astronauts from solar radiation
By Harry Pettit For Mailonline
Published: 14:03 EDT, 23 March 2017 | Updated: 14:04 EDT, 23 March 2017
unveil a giant leap for anti-aging
Date: March 23, 2017 Source: University of New South Wales Summary: Researchers have made a discovery that could lead to a revolutionary drug that actually reverses ageing, improves DNA repair and could even help NASA get its astronauts to Mars.
A conserved NAD binding pocket that regulates protein-protein interactions during aging.
Jun Li, Michael S. Bonkowski, Sébastien Moniot, Dapeng Zhang, Basil P. Hubbard, Alvin J. Y. Ling, Luis A. Rajman, Bo Qin, Zhenkun Lou, Vera Gorbunova, L. Aravind, Clemens Steegborn, David A.
SinclairScience, 24 Mar 2017: Vol. 355, Issue 6331, pp. 1312-1317 DOI: 10.1126/science.aad8242
compound reduces signs of aging in healthy mice
Safety of NMN being tested in small clinical trial
Date: October 27, 2016 Source: Washington University School of Medicine Summary: Much of human health hinges on how well the body manufactures and uses energy. For reasons that remain unclear, cells' ability to produce energy declines with age, prompting scientists to suspect that the steady loss of efficiency in the body's energy supply chain is a key driver of the aging process. Now, scientists have shown that supplementing healthy mice with a natural compound called NMN can compensate for this loss of energy production, reducing typical signs of aging such as gradual weight gain, loss of insulin sensitivity and declines in physical activity.
Administration of Nicotinamide Mononucleotide Mitigates
Age-Associated Physiological Decline in Mice.
Kathryn F. Mills et al. Cell Metabolism, October 2016 DOI: 10.1016/j.cmet.2016.09.013
controls nicotinamide mononucleotide and nicotinamide riboside
metabolism in mammalian cells
Joanna Ratajczak, Magali Joffraud, Samuel A. J. Trammell, Rosa Ras, Núria Canela, Marie Boutant, Sameer S. Kulkarni, Marcelo Rodrigues, Philip Redpath, Marie E. Migaud, Johan Auwerx, Oscar Yanes, Charles Brenner & Carles Cantó
11 October 2016
Nature Communications 7, Article number: 13103 (2016)
More info: Grand Index