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Nicotinamide Riboside
Nicotinamide Mononucleotide

Names: Niagen

Wikipedia entry: https://en.wikipedia.org/wiki/Nicotinamide_riboside

NOTE: Both Nicotinamide Mononucleotide (NAM) and Nicotinamide Riboside may be metabolized to NAD+

Nicotinamide Riboside Promotes Sir2 Silencing and Extends Lifespan via Nrk and Urh1/Pnp1/Meu1 Pathways to NAD+
Peter Belenky, Frances G. Racette, Katrina L. Bogan, Julie M. McClure, Jeffrey S. Smith, * and Charles Brenner,
DOI 10.1016/j.cell.2007.03.024
http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.135.6545&rep=rep1&type=pdf

Longevity and Nicotinamide riboside
https://cassiopaea.org/forum/index.php?topic=28650.0

Nicotinamide Mononucleotide (NMN) is a combination of nicotinamide (niacinamide) and ribose, according to Wikipedia. Both of these are available as supplements. Also, “nicotinamide riboside” is available from supplement distributors, and it isn’t too expensive.

Would YOU choose to live forever? Age-reversing pill that Nasa wants to give to astronauts on Mars will begin human trials within six months
Scientists have discovered a key signalling process in DNA repair
They have used this process in the development of a drug to reverse ageing
Trials on mice found that the pill repaired DNA damage after a week
Nasa wants the new technology to protect its astronauts from solar radiation
By Harry Pettit For Mailonline
Published: 14:03 EDT, 23 March 2017 | Updated: 14:04 EDT, 23 March 2017
http://www.dailymail.co.uk/sciencetech/article-4343142/Human-trials-age-reversing-pill-start-six-months.html

Scientists unveil a giant leap for anti-aging
Date: March 23, 2017 Source: University of New South Wales Summary: Researchers have made a discovery that could lead to a revolutionary drug that actually reverses ageing, improves DNA repair and could even help NASA get its astronauts to Mars.
https://www.sciencedaily.com/releases/2017/03/170323141340.htm

Journal Reference:
A conserved NAD binding pocket that regulates protein-protein interactions during aging.
Jun Li, Michael S. Bonkowski, Sébastien Moniot, Dapeng Zhang, Basil P. Hubbard, Alvin J. Y. Ling, Luis A. Rajman, Bo Qin, Zhenkun Lou, Vera Gorbunova, L. Aravind, Clemens Steegborn, David A.
SinclairScience, 24 Mar 2017: Vol. 355, Issue 6331, pp. 1312-1317 DOI: 10.1126/science.aad8242
http://dx.doi.org/10.1126/science.aad8242

Natural compound reduces signs of aging in healthy mice
Safety of NMN being tested in small clinical trial
Date: October 27, 2016 Source: Washington University School of Medicine Summary: Much of human health hinges on how well the body manufactures and uses energy. For reasons that remain unclear, cells' ability to produce energy declines with age, prompting scientists to suspect that the steady loss of efficiency in the body's energy supply chain is a key driver of the aging process. Now, scientists have shown that supplementing healthy mice with a natural compound called NMN can compensate for this loss of energy production, reducing typical signs of aging such as gradual weight gain, loss of insulin sensitivity and declines in physical activity.
https://www.sciencedaily.com/releases/2016/10/161027122047.htm

Journal Reference:

Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice.
Kathryn F. Mills et al. Cell Metabolism, October 2016 DOI: 10.1016/j.cmet.2016.09.013
http://dx.doi.org/10.1016/j.cmet.2016.09.013

NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells
Joanna Ratajczak, Magali Joffraud, Samuel A. J. Trammell, Rosa Ras, Núria Canela, Marie Boutant, Sameer S. Kulkarni, Marcelo Rodrigues, Philip Redpath, Marie E. Migaud, Johan Auwerx, Oscar Yanes, Charles Brenner & Carles Cantó
11 October 2016
Nature Communications 7, Article number: 13103 (2016)
doi:10.1038/ncomms13103
http://www.nature.com/articles/ncomms13103

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